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Complex stephanoporate bracket of calcium sulphate and freeze drying bone as well as preparation method thereof

A porous scaffold and calcium sulfate technology, applied in the field of medical devices, can solve the problems of affecting the growth of cells and tissues, poor plasticity, and reducing the pH value of polymers

Inactive Publication Date: 2008-05-14
孙海钰 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through in-depth research, it has been found that the biodegradability and osteogenesis of the above-mentioned several materials have deficiencies in the further research process; although PGA and PLA have good biocompatibility, degradability and absorbability However, there are disadvantages such as high cost and poor plasticity, and the acidic metabolites after degradation will reduce the pH value around the polymer, affect the growth of cells and tissues, and cause fibrosis and immune responses in surrounding tissues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of raw materials: (1) Calcium sulfate is a very common industrial raw material. It has a wide range of sources and is very cheap. It can be divided into three types in terms of chemical properties: ordinary calcium sulfate (dihydrate calcium sulfate), anhydrous calcium sulfate and Calcium sulfate hemihydrate; the latter is deep-processed from calcium sulfate dihydrate, calcium sulfate hemihydrate has a uniform crystal structure and high purity, and can be used for research and treatment in the field of medical orthopedics, also known as medical calcium sulfate; the specific preparation method is : The preparation method of calcium sulfate hemihydrate is as follows: mix calcium sulfate dihydrate powder with deionized water, place in a closed pressure vessel, add a conventional amount of polyacrylamide crystal modifier at the same time, at 160 degrees Celsius and 1.5 atmospheric pressure, make Calcium sulfate dihydrate is dissolved and recrystallized to form a ...

Embodiment 2

[0034] Preparation of raw materials: (1) Calcium sulfate is a very common industrial raw material. It has a wide range of sources and is very cheap. It can be divided into three types in terms of chemical properties: ordinary calcium sulfate (dihydrate calcium sulfate), anhydrous calcium sulfate and Calcium sulfate hemihydrate; the latter is deep-processed from calcium sulfate dihydrate, calcium sulfate hemihydrate has a uniform crystal structure and high purity, and can be used for research and treatment in the field of medical orthopedics, also known as medical calcium sulfate; the specific preparation method is : The preparation method of calcium sulfate hemihydrate is as follows: mix calcium sulfate dihydrate powder with deionized water, place in a closed pressure vessel, add a conventional amount of polyacrylamide crystal modifier at the same time, at 90 degrees Celsius and 4.5 atmospheric pressure, make Calcium sulfate dihydrate is dissolved and recrystallized to form a c...

Embodiment 3

[0041] Preparation of raw materials: (1) Calcium sulfate is a very common industrial raw material. It has a wide range of sources and is very cheap. It can be divided into three types in terms of chemical properties: ordinary calcium sulfate (dihydrate calcium sulfate), anhydrous calcium sulfate and Calcium sulfate hemihydrate; the latter is deep-processed from calcium sulfate dihydrate, calcium sulfate hemihydrate has a uniform crystal structure and high purity, and can be used for research and treatment in the field of medical orthopedics, also known as medical calcium sulfate; the specific preparation method is : The preparation method of calcium sulfate hemihydrate is as follows: mix calcium sulfate dihydrate powder with deionized water, place in a closed pressure vessel, add a conventional amount of polyacrylamide crystal modifier at the same time, at 150 degrees Celsius and 2 atmospheric pressure, make Calcium sulfate dihydrate is dissolved and recrystallized to form a cr...

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Abstract

The invention relates to a compound porous support and a preparation method, in particular to a calcium sulfate and freeze-dried bone compound porous support and the preparation method, belonging to the medical instrument technical field. The compound sizing agent of the half water calcium sulfate powder and the mashed freezing person homogeneous allograft bone is made; after the calcium sulfate sizing agent is evenly painted on polyurethane foam, the calcium sulfate ceramic porous support is obtained through the drying and the high-temperature treatment; after immersed in the compound sizing agent to get coating, the calcium sulfate ceramic porous support is positioned in the inner door environment for being dried naturally; then after heating and drying, the invention is produced.

Description

technical field [0001] The invention relates to a composite porous support and a preparation method thereof, in particular to a calcium sulfate and freeze-dried bone composite porous support and a preparation method thereof. It belongs to the technical field of medical equipment. Background technique [0002] Due to trauma, infection, tumor and other factors, the bone loses some bone quality and forms a large gap, which is called bone defect. The vast majority of bone defects are difficult to heal and eventually form nonunion. Due to the large defect gap, it is difficult for osteoblasts to crawl through the gap and the normal healing process cannot occur, and it is only filled by fibrous tissue. The treatment of bone defects is a difficult and challenging topic in the field of orthopedics. Clinically, autologous, allogeneic tissue transplantation and biological substitute materials are used to achieve certain therapeutic purposes. At present, the most commonly used autolo...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/28A61L27/36
Inventor 孙海钰孙海飙王东
Owner 孙海钰
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