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Magnetic temperature sensing nano-particle with bioavailability and synthesizing method thereof

A biocompatibility and nanoparticle technology, applied in the field of magnetic temperature-sensitive nanoparticles and their synthesis, can solve the application limitations, magnetic temperature-sensitive nanoparticles are not biocompatible, and the magnetic response of magnetic microspheres is not too strong and other problems, to achieve the effect of simple and reliable synthesis method and strong magnetic response

Inactive Publication Date: 2008-05-07
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN1290524 discloses a preparation method and application thereof of chitosan microspheres, and Chinese patent CN1600800 and Chinese patent CN1763126 respectively disclose a method for compounding polysaccharides to prepare polymer microspheres. The disadvantages of the above-mentioned patents are that these The method is to obtain polysaccharide magnetic microspheres obtained by cross-linking and encapsulating magnetic particles with natural biological materials. The magnetic responsiveness of the magnetic microspheres is not too strong
Chinese patent CN1995144 discloses a method for synthesizing magnetic temperature-sensitive nanoparticles. A magnetic temperature-sensitive nanoparticle with dual response properties of magnetism and temperature sensitivity is synthesized. The disadvantage is that the magnetic temperature-sensitive nanoparticle does not have a biological phase. capacitive, which limits its application in biomedical

Method used

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  • Magnetic temperature sensing nano-particle with bioavailability and synthesizing method thereof
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Experimental program
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Effect test

Embodiment 1

[0031] (1) Preparation of magnetic Fe 3 o 4 Nanoparticles: weigh 0.20g FeCl 2 4H 2 O and 0.50 g FeCl 3 ·6H 2 O, dissolved in 200mL distilled water at the same time, at 50°C, under the protection of nitrogen, add 4.0mol / L NaOH solution at one time, stir vigorously to make the system pH=11. Reaction at 80°C for 60 minutes, magnetic separation, the product was washed with distilled water several times to neutrality, and then dried in a vacuum oven at 60°C for 72 hours to obtain magnetic Fe 3 o 4 Nanoparticles;

[0032] (2) Magnetic Fe 3 o 4 Surface modification of nanoparticles: Weigh 0.2g magnetic Fe 3 o 4 Nanoparticles were added to 40mL of ethanol / distilled water with a volume ratio of 1:1 as the dispersion medium, and ultrasonically dispersed for 30min to remove the magnetic Fe. 3 o 4 Nanoparticle surface impurities. Magnetic Fe obtained after magnetic separation 3 o 4 Add ethanol / distilled aqueous solution (the volume ratio of ethanol and distilled water is 1:...

Embodiment 2

[0039] (1) Preparation of magnetic Fe 3 o 4 Nanoparticles: weigh 0.05g FeCl 2 4H 2 O and 0.15gFeCl 3 ·6H 2 O, dissolved in 200mL water at the same time, at 50°C, under the protection of nitrogen, add 4.5mol / L ammonia solution in one go, stir vigorously to make the system pH=12. Reaction at 75°C for 70 minutes, magnetic separation, the product was washed with deionized water several times to neutrality, and then dried in a vacuum oven at 60°C for 72 hours to obtain magnetic Fe 3 o 4 Nanoparticles;

[0040] (2) Magnetic Fe 3 o 4 Surface modification of nanoparticles: Weigh 0.3g magnetic Fe 3 o 4 Nanoparticles were added to 40mL of ethanol / distilled water with a volume ratio of 1:1 as the dispersion medium, and ultrasonically dispersed for 30min to remove the magnetic Fe. 3 o 4 Nanoparticle surface impurities. Magnetic Fe obtained after magnetic separation 3 o 4 Then add ethanol / distilled aqueous solution (the volume ratio of ethanol and distilled water is 1:1) to ...

Embodiment 3

[0044] (1) Preparation of magnetic Fe 3 o 4 Nanoparticles: weigh 0.10g FeCl 2 4H 2 O and 0.40 g FeCl 3 ·6H 2 O, dissolved in 200 mL water at the same time, at 55°C, under the protection of nitrogen, add 4.5mol / L NaOH solution at one time, stir vigorously to make the system pH=11. Reaction at 85°C for 40 minutes, magnetic separation, the product was washed with deionized water several times to neutrality, and then dried in a vacuum oven at 60°C for 72 hours to obtain magnetic Fe 3 o 4 Nanoparticles;

[0045] (2) Magnetic Fe 3 o 4 Surface modification of nanoparticles: Weigh 0.1g magnetic Fe 3 o 4 The nanoparticles were added to 40mL of methanol / water solution with a volume ratio of methanol to water of 1.2:1 as the dispersion medium, and ultrasonically dispersed for 30min to remove the magnetic Fe. 3 o 4 Nanoparticle surface impurities. Magnetic Fe obtained after magnetic separation 3 o 4 Then add methanol / water solution (the volume ratio of methanol to water is ...

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Abstract

The invention relates to a magnetic thermometer nm particle with biocompatibility, which has biocompatibility, and double response properties of magnetism and thermometer property, and the particle diameter thereof is 20 to 60 nm, and the magnetic responsibility is strong, and magnetic saturation intensity is 10.0 to 27.0 emu / g. The synthetic method of the magnetic thermometer nm particle with biocompatibility comprises: firstly, adopting chemical coprecipitation method to prepare magnetic Fe3O4 nm particle, and using silane coupler to hold surface modification, and then using the modified magnetic Fe3O4 nm particle as a seed, and having polyreaction with dextran, N-isopropyl acrylamide, finally obtaining the magnetic thermometer nm particle with biocompatibility. The magnetic thermometer nm particle with biocompatibility synchronously has double responses of magnetism and thermometer property, and has wide application prospect in the fields of drug release, protein and enzyme separation.

Description

technical field [0001] The invention belongs to the technical field of environmental responsive materials, and in particular relates to a biocompatible magnetic temperature-sensitive nano particle and a synthesis method thereof. Background technique [0002] Magnetic polymer nanoparticles are a widely used environmental responsive material, which refers to magnetically responsive polymer particles containing ultrafine particles of magnetic metals or metal oxides. In addition to the characteristics of polymer particles, magnetic polymer nanoparticles can be endowed with a variety of reactive functional groups on the surface through copolymerization and surface modification, and because they are magnetic, they can be easily separated under the action of an external magnetic field. It has the special property of being able to orientate to a specific area in the presence of an external magnetic field, making it, like other environment-responsive polymers, have broad application ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F2/44C08F2/38C08K9/00H01F1/42
Inventor 李玮张黎明朱玉光
Owner SUN YAT SEN UNIV
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