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Method for preparing traditional Chinese medicine preparation for treating gout

A technology of traditional Chinese medicine preparations and gout, which is applied in the direction of medical formulas, medical preparations containing active ingredients, pill delivery, etc. It can solve the problems of low bioavailability, poor absorption of preparations, secondary pollution, etc., and achieve full utilization of raw materials , short operating time, and reduced operating intensity

Inactive Publication Date: 2008-04-30
XIUZHENG PHARMA GROUP HOIDING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many preparation methods for existing medicines for the treatment of gout, mainly pulverizing the crude drug or its extract into fine powder, adding excipients to make various conventional dosage forms, these conventional methods for preparing preparations for the treatment of gout involve Multiple processes, and more auxiliary materials are required, and there is a possibility of secondary pollution during the preparation process
Most of the traditional medicines prepared by the above conventional preparation methods can only take effect or take effect after large doses and long-term medication, and the preparations have defects such as poor absorption and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]900g of rhubarb, 600g of psyllium, and 600g of Achyranthes chinensis were ultrasonically extracted twice, each time for 0.5 hours, the decoctions were combined, concentrated under reduced pressure in vacuum to an extract with a relative density of 1.15-1.25 (60°C), and spray-dried. Grind into fine powder; Alisma 600g and Fangji powder 300g are crushed into fine powder. The above two kinds of fine powder are mixed with auxiliary materials microcrystalline cellulose 200g, low-substituted hydroxypropyl cellulose 200g, and sodium carboxymethyl starch 80g, and 5% polyvinylpyrrolidone 50% ethanol solution is used as a binder, and a fluidized spray is used. Granulation technology: Granulate, add 50g of sodium carboxymethyl starch and 10g of magnesium stearate, mix evenly, compress into tablets, and coat with film to obtain.

Embodiment 2

[0041] 900g of rhubarb, 600g of psyllium, 600g of Achyranthes bidentata, 600g of Alisma 600g, and 300g of Fangji powder are used to pulverize the five flavors of traditional Chinese medicine into a fine powder below 10 μm, and mix them with 200g of microcrystalline cellulose as an auxiliary material. Carboxymethyl cellulose and 0.5% carboxymethyl cellulose were used as binders. Granulated by fluidized spray granulation technology. Add 12g of magnesium stearate, mix evenly, compress into tablets, and coat with film to obtain the product.

Embodiment 3

[0043] Add 900g of rhubarb, 600g of psyllium, 600g of Achyranthes chinensis, 600g of Alisma, 300g of Fangji powder, add water and ultrasonically extract twice, each time for 0.5 hours, combine the decoction, and concentrate under vacuum to a relative density of 1.15-1.25 (60°C) extract, spray-dried. Crush to a fine powder. Fine powder and auxiliary materials microcrystalline cellulose 300g, low-substituted hydroxypropyl cellulose 300g, sodium carboxymethyl starch 80g, with 5% polyvinylpyrrolidone 70% ethanol solution as binder, adopt fluidized spray granulation technology to granulate , plus 50 g of sodium carboxymethyl starch and 10 g of magnesium stearate, mix evenly, compress into tablets, and coat with a film, to obtain.

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PUM

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Abstract

The invention discloses a process for preparing a traditional Chinese medicine medicament for curing the disease of gout. Five parts of the raw material medicaments comprising rhubarb horsetail, plantago asiatica linne, rhizoma alismatis, cyathula root and tetrandra root are ultrasonic extracted or ultramicro disintegrated directly under a certain condition, and the granules are produced adopting the fluidized spray, then the traditional Chinese medicine medicament for curing the disease of gout is achieved. The invention is simple in preparation procedure, short in operating time, and high in granule making efficiency, thereby the utilization efficiency of the raw material medicament is improved, and the achieved medicament has the advantages of fine absorption and high bioavailability.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine preparation technology, in particular to a preparation method of a traditional Chinese medicine preparation for treating gout. Background technique [0002] Gout is a group of diseases caused by purine metabolic disorders, and its clinical features are hyperuricemia and the resulting gouty acute arthritis recurrent attack, tophi deposition, tophi chronic arthritis And joint deformities, often involving the kidneys cause chronic interstitial nephritis and uric acid nephrolithiasis. According to the analysis report of China Disease and Health Survey Center in 2004, the number of patients with hyperuricemia in my country has reached 120 million, of which more than 75 million are patients with gout, and they are increasing at an annual growth rate of 0.97%. Gout has become the same disease as diabetes in my country. The same second largest metabolic disease, and seriously endanger peop...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61K9/16A61K9/28A61K9/48A61P19/06
Inventor 姜波王鑫常红
Owner XIUZHENG PHARMA GROUP HOIDING
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