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Anti-cicatrix externally used pad pasting containing hormone medicament and method for preparing the same

A technology of hormones and drugs, applied in the field of anti-scar topical film and its preparation, can solve problems such as telangiectasia, inability to use infected wounds, pigmentation, etc., achieve simple preparation process, reduce adverse drug reactions, and low cost Effect

Inactive Publication Date: 2010-05-26
李世荣 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because of the side effects of triamcinolone acetonide, the silicone gel drug scar patch with hormone triamcinolone acetonide can cause allergic reactions, such as skin burning sensation, itching, acupuncture, etc., and skin atrophy, capillary Vasodilation, pigmentation and secondary infection, and easily cause changes in the patient's hormone levels
Therefore, there are limitations in the use process, and it cannot be used for infected wounds, and it cannot be used for the treatment of scars in children

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Heat the silica gel to 50°C in a groove mold, and make the silica gel into a backing film;

[0029] (2) Get 0.01mg of acepropyl methylprednisolone;

[0030] (3) Add the medicine in step (2) to the silicone gel pressure-sensitive adhesive and stir and mix evenly;

[0031] (4) the mixture of step (3) is ultrasonically vibrated to exhaust;

[0032] (5) Add the exhausted silicone gel pressure-sensitive adhesive into the grooved mold of step (1) and add evenly on the silicone backing to form a film at 50°C;

[0033] (6) The pressure-sensitive adhesive layer is pasted with anti-adhesive paper, sealed and packaged, and then sterilized by radiation to obtain the finished anti-scar topical film.

Embodiment 2

[0035] (1) Heat the silica gel to 80°C in a groove mold, and make the silica gel into a backing film;

[0036] (2) Get 0.1 mg of acetopropyl methylprednisolone;

[0037] (3) Add the medicine in step (2) to the silicone gel pressure-sensitive adhesive and stir and mix evenly;

[0038] (4) the mixture of step (3) is ultrasonically vibrated to exhaust;

[0039] (5) Add the exhausted silicone gel pressure-sensitive adhesive into the grooved mold of step (1) and add evenly on the silicone backing to form a film at 80°C;

[0040] (6) The pressure-sensitive adhesive layer is pasted with anti-adhesive paper, sealed and packaged, and then sterilized by radiation to obtain the finished anti-scar topical film.

Embodiment 3

[0042] (1) Heat the silica gel to 100°C in a groove mold, and make the silica gel into a backing film;

[0043] (2) Take 1 mg of betamethasone;

[0044] (3) Add the medicine in step (2) to the silicone gel pressure-sensitive adhesive and stir and mix evenly;

[0045] (4) the mixture of step (3) is ultrasonically vibrated to exhaust;

[0046] (5) Add the exhausted silicone gel pressure-sensitive adhesive to the grooved mold of step (1) and add evenly on the silicone backing to form a film at 100°C;

[0047] (6) The pressure-sensitive adhesive layer is pasted with anti-adhesive paper, sealed and packaged, and then sterilized by radiation to obtain the finished anti-scar topical film.

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PUM

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Abstract

The invention discloses an anti-cicatricial topical drug film containing hormone medicine and the preparation method. The anti-cicatricial topical drug film contains silica gel medicine film, which isadded with hormone medecines. The anti-cicatricial topical drug film of the invention is capable of effectively curing scar. After the drug combination in the drug film is screened and the drug combination is optimized, the anti-cicatricial topical drug film does not change the hormone levels of patients. Thereby, the invention is not only fit for curing scars of common population and children, but also capable of curing wounds except severe infection. Besides, the product improves the treating effect of gel scar drug film and widens the scope of treating population. The anti-cicatricial topical drug film of the invention is characterized by simple preparation process and low cost.

Description

technical field [0001] The invention relates to an external drug patch and a preparation method thereof, in particular to an anti-scar external film containing hormone drugs and a preparation method thereof. Background technique [0002] The treatment of skin scars is a difficult surgical problem. At present, silicone gel scar patch is an effective means for the treatment of skin scars, but the clinical effect is limited. How to further improve the therapeutic effect of silicone gel scar patch is an urgent problem to be solved at present, but there is no research progress in this area at home and abroad, and patients have a strong demand for this type of external treatment, so the development prospect of this product is very promising. broad. In addition to the prevention and treatment of scars in postoperative and traumatic patients, as far as burn patients are concerned, according to statistics from authoritative departments in my country, the annual incidence rate is 5-1...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/573A61K31/4422A61K9/70A61K45/06A61P17/02
Inventor 李世荣陈康
Owner 李世荣
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