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Avermectin nanometer medicine-carried system with slow-releasing and controlled-releasing action

A technology of abamectin and nano-drug loading, which is applied in the fields of application, animal repellent, botany equipment and methods, etc.

Inactive Publication Date: 2008-03-19
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention patent of the nano-loading system of granulated water-dispersible granules (WG) with slow and controlled release developed for abamectin has not been reported at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Accurately weigh the abamectin nano drug-loaded particles containing 3.5 grams of abamectin (abamectin effective load rate 60%), sodium lignosulfonate 100.0 grams, naphthalenesulfonate formaldehyde condensate 20.0 grams according to the formula requirements gram, 5.0 grams of soluble starch, and 90.0 grams of ammonium sulfate were added to 1000 grams with white carbon black, mixed for 10 minutes under gravity-free conditions, and pulverized with a jet mill. If all the technical indexes are qualified, the 3.5% avermectin nanometer drug loading system is obtained.

Embodiment 2

[0083] Accurately weigh the abamectin nano drug-loaded particles containing 5.0 grams of avermectin (abamectin effective load rate 60%), 100.0 grams of sodium lignosulfonate, polymethacrylic acid carboxylate 20.0 grams of branch copolymer, 5.0 grams of sodium carboxymethyl cellulose, and 100.0 grams of ammonium sulfate were added to 1000 grams with bentonite, mixed for 10 minutes under gravity-free conditions, and pulverized with a jet mill. If all the technical indexes are qualified, the 5% abamectin nanometer drug loading system is obtained.

Embodiment 3

[0085] Accurately weigh the abamectin nano drug-loaded particles containing 10.0 grams of abamectin (abamectin effective loading rate 60%), 120.0 grams of sodium lignosulfonate, polymethacrylic acid carboxylate 25.0 grams of branch copolymer, 5.0 grams of sodium carboxymethyl cellulose, and 120.0 grams of ammonium sulfate were added to 1000 grams with bentonite, mixed for 10 minutes under gravity-free conditions, and pulverized with a jet mill. If all the technical indexes are qualified, the 10% abamectin nano drug loading system is obtained.

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Abstract

The invention relates to an avermectin water dispersible granule (WG) nano drug-loaded system which is prepared by mixing, grinding and granulation of reasonable proportion of a dispersant, a disintegrating agent, a filling material and an avermectin nano drug-loaded particle. The avermectin nano drug-loaded particle is formed after a nano silica carrying material with porous structure effectively carries a pesticide active ingredient of avermectin with physical absorption. The avermectin nano drug-loaded system appears like a cylinder-shaped particle and automatically disperses and forms suspension in water when in use, moreover, the invention has significant slow and controlled release effect on the avermectin and can also effectively reduce hydrolysis and photolysis of the avermectin in water solution.

Description

technical field [0001] The invention relates to a kind of abamectin nano drug-loaded particle formed after a nano-silica carrier material with a porous structure effectively carries the active ingredient abamectin of the pesticide through physical adsorption, and is mixed with a dispersant and a disintegrating agent in a reasonable ratio The avermectin water-dispersible granules (WG) nano-loading system formed by mixing, pulverizing and granulating fillers. It belongs to the research field of pesticide formulations, and mainly controls the release rate of abamectin after use, slows down the hydrolysis and photolysis of abamectin, improves the utilization rate, and increases the safety in preparation processing and use. Background technique [0002] The introduction of nanoscale technology in 1990 provided a thinking and method different from the traditional meaning for life science and biomedicine research. In the field of medical research, nanotechnology is used in drug re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N25/08
Inventor 黄啟良李凤敏折冬梅梅向东
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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