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Novel compound separated from camphor tree body and medical component

A technology for compounds and compositions, applied in the field of novel diterpenoids, can solve problems such as no scientific evidence

Inactive Publication Date: 2008-03-12
KANG JIAN BIOTECH CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] According to folk experience, Antrodia camphorata has functions such as detoxification, anti-cancer, anti-alcoholic, anti-inflammatory, etc., but there is no scientific evidence to prove it

Method used

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  • Novel compound separated from camphor tree body and medical component
  • Novel compound separated from camphor tree body and medical component
  • Novel compound separated from camphor tree body and medical component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Isolation and structural analysis and identification of novel diterpenoids

[0021] The fruiting body of Antrodia camphorate No.2 was provided by Kang Jian BiotechCorp.Ltd. (Kang Jian Biotech Co., Ltd.), Nantau, Taiwan, Republic of China. The fungus was provided by Dr. Lai Minnan of Kang Jian Biotech Corp.Ltd. For identification. Proof specimens (No.2) are deposited in Kang Jian Biotech Corp.Ltd. (Kang Jian Biotech Co., Ltd.).

[0022] Extract 2 kg of Antrodia camphorata fruiting bodies with 40 liters of methanol at room temperature twice for 5 days. After evaporation of the solvent, the residual extract was mixed with water to make a total volume of 1 liter. This phase was extracted 3 times with 1 L of EtOAc, the combined organic phases were evaporated and the resulting black syrup, 150 g, was chromatographed on silica gel with hexane and ethyl acetate (EtOAc). Fractions were eluted with 30-40% EtOAc in hexane and purified by HPLC using a preparative silica gel colum...

Embodiment 2

[0031] Efficacy of the isolated compound for protecting nerve cell damage

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Abstract

The present invention discloses a novel diterpenoid compound separated from the Antrodia camphorate fruiting body, more particularly, a compound with the following structural formula (see the chemical formula), and the medically acceptable salt, solvent compound, hydrate or compound of the same biological activity or the derivative and so on. The present invention also discloses the application of the novel compound in the neural protection and the composition of the medicine with the compound as the active ingredient.

Description

Technical field: [0001] The present invention relates to a novel diterpenoid compound isolated from the fruiting bodies of Antrodia camphorata, its isolation method, and its use in the protection of brain neurons. Background technique: [0002] Antrodia camphorata, also known as Antrodia camphorata or Cinnamomum cinnamomea, belongs to the order Aphyllobacteria, Polyporaceae, and perennial fungi. Because it is a unique and precious local medicinal fungus, it has commercial and research value, and it is currently the most expensive wild fungus in Taiwan. [0003] Antrodia camphorata only grows at an altitude of 450-2000 meters in the mountains of Taiwan. It is unique to the inner wall of the decayed heartwood of the camphor tree trunk that is more than a century old, or the damp surface of the dead and fallen camphor tree wood. The growth environment belongs to dark, humid and middle-altitude areas with slightly lower temperature, and its growth is slow, so it takes a long ti...

Claims

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Application Information

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IPC IPC(8): C07D307/28A61K31/365A61P25/00A61P25/28A61K36/07
Inventor 赖敏男郭悦雄萧永基
Owner KANG JIAN BIOTECH CORP LTD
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