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Antineoplastic preparations and method of preparing the same

An anti-tumor and preparation technology, which is applied in the field of anti-tumor compound Chinese herbal medicine formulations and its preparation, can solve the problems of unstable tumor curative effect, unstable curative effect, and difficulty in determining effective components, so as to improve the function of human hematopoietic cells and solve the problem of toxic and side effects. , the effect of reducing toxic side effects

Inactive Publication Date: 2008-03-12
GUANGXI HUIBAOYUAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, at present, the curative effect of using Chinese herbal medicine to treat tumors is unstable, and the active ingredients are difficult to determine. The difficulties are: quantifying the use of active ingredients, and finding effective methods for manufacturing and quality control of Chinese patent medicines with stable quality
Some effective chemical monomers extracted from Chinese herbal medicines or plants are used as anti-tumor drugs, which can overcome the shortcomings of Chinese herbal medicines in treating tumors, such as unstable curative effect, etc.
However, after this "Westernization" of traditional Chinese medicine is made into effective chemical monomers, it still has the same limitations as chemotherapy in treatment, which is comparable to the lack of synthetic chemotherapy drugs.
Toxic side effects and drug resistance of tumor cells are still insurmountable bottlenecks

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1, the preparation technology and method of anticancer preparation 1

[0039] Recipe 1: Waerteng (main medicine) 25 grams

[0040] Chonglou (medicine) 10g

[0041] Qingtiankui (adjuvant) 10g

[0042] 20 grams of wax gourd (adjuvant)

[0043] Licorice (adjuvant) 5 grams

[0044] Preparation method: in the above formula, after soaking pre-treated Waer vine in 7-10 times (weight ratio) warm water for 12 hours, rinse with warm water for 3 times and dry. Ultrasonic extraction was performed with 95% ethanol for 1 hour, and the ethanol was recovered by concentration to obtain the active site A of Radix vulgaris. Cholesterol was extracted with 95% ethanol ultrasonically for 1 hour, concentrated to recover ethanol, and the active part B of Cholesterol was obtained. The active site C was obtained by ultrasonically extracting serrata, wax gourd and licorice with 70% ethanol, and the ethanol was recovered and concentrated. After mixing A and B, adding C, and after ...

Embodiment 2

[0045]Example 2: Preparation technology and method 2 of anticancer preparations

[0046] Recipe 2: Wa'erteng (main medicine) 250 grams

[0047] Chonglou (medicine) 100g

[0048] Qingtiankui (adjuvant) 100g

[0049] wax gourd (adjuvant) 250g

[0050] Banzhilian (adjuvant) 500g

[0051] Hedyotis diffusa (adjuvant) 500g

[0052] White hair vine (adjuvant) 500 grams

[0053] Licorice (adjuvant) 100g

[0054] Preparation method: In the above formula, 8-10 times (weight ratio) ethanol with a concentration of more than 95% is ultrasonically extracted for 0.5-1 hour of Radix vulgaris After filtering, the filtrate was obtained to obtain active component A. The auxiliary drug is extracted with ethanol with a concentration of more than 95% by ultrasonic for 0.5-1 hour, and the ethanol is recovered and concentrated to obtain the active site B. Using 50% ethanol to ultrasonically extract the adjuvant combination including the wax gourd, the amphibian, the bark lotus, the Hedyotis d...

Embodiment 3

[0055] Example 3: Preparation technology and method of anti-tumor nano-formulation

[0056] Recipe 3: Wa'erteng (main medicine) 2000 grams

[0057] Chonglou (medicine) 1500g

[0058] Preparation method: in the above-mentioned formula, the waste residue after 7-10 times (weight ratio) of boiling water is extracted with warm water for 3 times and then dried with warm water, then extracted with more than 95% ethanol boiling point for 2-4 hours, the ethanol is recovered and concentrated, The active site A of Radix vulgaris was prepared. Extracting the erythromycin with a boiling point of 95% or more ethanol for 2-4 hours, recovering the ethanol and concentrating to obtain the active site B. The active site A and the active site B of C. chinensis can also be extracted at the same time to prepare AB mixture. After mixing components A and B, add nanocarriers. Available nanocarriers include but are not limited to nano-SiO 2 , CaCO 3 , cellulose, starch, polysaccharide, dextrin, o...

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Abstract

The present invention combines the traditional theory of Chinese medicine compatibility with the modern pharmacology and the vegetable chemistry. The present invention provides a novel compound Chinese herbal recipe technology, as well as a formulation and a preparation method produced according to the technology for treating or assistantly treating tumor. The non-water-soluble active part of a manyflower tylophora root is used as the main drug or the principal drug; the non-water-soluble active part of a paris chinensis is used as the supplementary drug or the adjuvant drug; according to needs, the non-water-soluble active part of hairyflower actinidia root, ford nervilia leaf, sunplant, Herba Hedyotis, bittersweet root and or liquorice is used as the supplementary drug or the adjuvant drug for medicine compatibility. The present invention can decrease the toxic side effects caused by the large dosage of main drug in the process of treating tumor while increasing the main curative effect. The anti-tumor preparation provided by the present invention can effectively eliminate and inhibit tumor cells, protect and increase the hematopoietic cell function, and improve the immune system of human body.

Description

technical field [0001] The invention relates to an anti-tumor compound Chinese herbal medicine formula and a preparation method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] After thousands of years of development, traditional Chinese medicine has a broad and profound theory, and advocates holistic treatment and drug compatibility. That is, according to the medicinal properties of medicines, they are divided according to the "four qi and five flavors", and at the same time, according to the principle of returning to the meridian of the disease, the meridian of traditional Chinese medicine is also distinguished. According to the symptoms, Chinese pharmacists list one or several herbs that have curative effects on the symptoms, and make primary and secondary combinations with reference to the meridian-returning, five flavors and four qi properties of these drugs, that is, the so-called monarch, ministers, assistants and envoys, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P35/00
Inventor 詹姆斯·周
Owner GUANGXI HUIBAOYUAN PHARMA TECH CO LTD
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