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Method for reducing or avoiding adverse effect of steroid compound

A technology of steroids and compositions, applied in the directions of steroids, drug combinations, organic chemistry, etc., can solve the problems of elevated, unknown steroid-induced intraocular pressure, etc., achieve excellent efficacy, reduce or avoid Elevated intraocular pressure, or the effect of avoiding induced intraocular pressure elevation

Inactive Publication Date: 2008-02-06
SANTEN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is currently no known technique for suppressing steroid-induced IOP elevation without using the above methods

Method used

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  • Method for reducing or avoiding adverse effect of steroid compound

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0040] Dissolve betamethasone (0.05g) and polylactic acid (0.25g) with a weight average molecular weight of about 20,000 (dispersion about 2.0) in dichloromethane (0.5mL) and benzyl alcohol (3.0mL), and the resulting solution is drug / polymer solution. A 0.2% (w / v) polyvinyl alcohol aqueous solution (400 mL) was homogenized (10000 rpm) with a homogenizer, and the drug / polymer solution was dropped thereinto. The mixture was homogenized for 10 minutes after the dropwise addition to prepare an O / W emulsion. The O / W emulsion was stirred with a stirrer for 3 hours (200 rpm). After the stirring was completed, the obtained suspension was centrifuged, and the supernatant was removed. In order to wash the precipitate, ultrapure water (30 mL) was added to disperse the precipitate, the resulting dispersion was centrifuged again, and the supernatant was removed. Repeat this operation once. The washed precipitate was sieved to obtain particles. The obtained particles were freeze-dried...

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Abstract

It is intended to provide a method of relieving or avoiding a steroid-induced increase in ocular tension which is caused by the administration of a steroid compound. Namely, a steroid-induced increase in ocular tension can be relieved or avoided by enclosing a steroid compound in fine particles.

Description

technical field [0001] The present invention relates to a method for alleviating or avoiding steroid-induced intraocular pressure elevation by containing the steroid compound in microparticles and the composition. Background technique [0002] Steroids are widely used as therapeutic agents for various inflammatory diseases. Steroid compounds used in the field of ophthalmology include, for example, betamethasone, dexamethasone, triamcinolone, fluorometholone, fluocinolone acetonide, etc. . [0003] Although the above-mentioned steroids are very useful drugs, on the other hand, steroids have a side effect of steroid-induced increase in intraocular pressure. In severe cases, the intraocular pressure will rise, leading to irreversible visual dysfunction. [0004] Therefore, ophthalmologists must pay attention to this side effect when administering steroids, but it is very difficult to predict the onset because there are still many unclear points in its pathogenesis or patholo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K9/14A61K47/34C07J5/00
CPCA61K9/0048A61K9/1647A61K31/573A61P27/06A61P43/00A61K9/20
Inventor 山田和人T.奥哈西酒井宏之松野圣木村章男
Owner SANTEN PHARMA CO LTD
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