Articular cavity inner injecting and administering preparations containing low-molecular-weight heparin or the low-molecular-weight heparin salt

Abstract

The present invention provides an intra-articular injection administration preparation containing low molecular weight heparin or the salt, which is characterized in that the preparation contains the low molecular weight heparin or the salt. The present invention is characterized by anti-swelling, anti-inflammatory, anti-allergic and immune modulation of the low molecular weight heparin or the salt, the invention is used for intra-articular injection administration, which can significantly improve and treat the rheumatism, rheumatoid arthritis, osteoarthritis, synovitis and / or cartilage injury.

Description

Technical field: [0001] The invention belongs to the technical field of medicine and provides a preparation for intra-articular injection containing low-molecular-weight heparin or a salt thereof. Background technique: [0002] Arthritis is one of the common joint diseases clinically, which is more common in the elderly. With the prolongation of the average human life expectancy and the continuous aggravation of the aging society, the incidence of osteoarthritis in the elderly is also increasing, which seriously reduces the quality of life of the elderly. Therefore, the treatment of arthritis has become a major problem to be solved urgently. [0003] Arthritis caused by various reasons starts from the degeneration and damage of articular cartilage, followed by the changes of bone and synovium. The degeneration of cartilage includes the changes of chondrocytes and matrix. At present, there are many methods for the drug treatment of arthritis, and a commonly used method is t...

AI Technical Summary

Problems solved by technology

At present, there are many methods for the drug treatment of arthritis, and a commonly used method is to control inflammation by giving glucocorticoids, but two obvious disadvantages of this method are: 1) Although it can quickly cover up the pain symptoms of arthritis, relieve Inflammation, but can not fundamentally improve the pathological changes of cartilage and synovial fluid, on the contrary, patients often aggravate the activity because of pain relief, aggravate the degree of pathological changes of cartilage and synovial fluid, and further aggravate arthritis; 2) Glucocorticoids have obvious The adverse reactions greatly limit its application, and it is urgent to develop new and better drugs

However, the effects of these drugs are relatively single, and some drugs have obvious adverse reactions after long-term use

This leaves patients with this type of arthritis still without good medications