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Application of p-hydroxybenzene ethanone and its derivant in preparation of agentia treating gallstone disease

A technology for p-hydroxyacetophenone and m-hydroxyacetophenone, which is applied to p-hydroxyacetophenone and its derivatives in the pharmaceutical field, can solve the problems of teratogenic effect, lack of obvious curative effect, and difficulty for patients to take it for a long time. Achieve the effect of increasing bile secretion, low price and good medicinal prospects

Inactive Publication Date: 2008-01-23
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, these stone-dissolving drugs often have some side effects that often make it difficult for patients to persist in taking them for a long time, especially gastrointestinal reactions, such as diarrhea, and abnormal liver function after long-term use. have teratogenic effects and are therefore subject to great restrictions
[0007] Traditional Chinese medicine has played a very prominent role in the treatment of cholelithiasis. The compound mainly composed of Desmodium sativa has achieved certain effects, but we have not obtained obvious curative effect in the cholelithiasis-dissolving test with the components separated and extracted from Desmodium.

Method used

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  • Application of p-hydroxybenzene ethanone and its derivant in preparation of agentia treating gallstone disease
  • Application of p-hydroxybenzene ethanone and its derivant in preparation of agentia treating gallstone disease
  • Application of p-hydroxybenzene ethanone and its derivant in preparation of agentia treating gallstone disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Drug to be tested: p-Hydroxyvalerophenone (manufactured by Tokyo Chemical Industry Co., Ltd.)

[0046] Dosage: 19.6mg / kg;

[0047] Number of Animals: 4

[0048] a. Effects on bile secretion in rats (X±SD)

[0049]

period

Bile flow / μl

1

2

3

4

X

SD

P1

P2

Before administration

30 minutes

after administration

30 minutes

after administration

30-60 minutes

after administration

60-90 minutes

530

560

350

360

510

680

380

400

420

700

700

470

480

540

550

350

485

620

495

395

48....

Embodiment 2

[0062] Drug tested: p-nitroacetophenone (produced by Lancaster)

[0063] Dosage: 12.9mg / kg;

[0064] Number of Animals: 14

[0065] a. Effects on bile secretion in rats (X±SD)

[0066] period

Bile flow / μl

1

2

3

4

5

6

7

8

9

10

11

12

13

14

X

SD

P1

P2

Before administration

30 minutes

after administration

30 minutes

after administration

30-60 minutes

after administration

60-90 minutes

after administration

90-120 minutes

820

1300

820

700

520

1000

850

780

710

1200

900

360

100

180

340

330

600

600

500

460

420

500

500

480

...

Embodiment 3

[0084] Test drug: p-Hydroxyacetophenone (manufactured by Lancaster)

[0085] Dosage: 15mg / kg;

[0086] Number of Animals: 13

[0087] a. Effects on bile secretion in rats (X±SD)

[0088] period

Bile flow / μl

1

2

3

4

5

6

7

8

9

10

11

12

13

X

SD

P1

P2

Before administration

30 minutes

after administration

30 minutes

after administration

30-60 minutes

after administration

60-90 minutes

after administration

90-120 minutes

520

1200

850

400

500

1090

840

460

440

610

690

400

620

1220

400

600

350

600

600

580

320

300

420

460

280

280

280

680

...

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Abstract

The invention discloses an application of hydroxyacetophenone and its derivatives in preparing drugs for curing cholelithiasis, which can enhance the excretion of bile and lower down the content of cholesterin and bilirubin in the bile, thus realizing the dual effects of bile expelling and lithiasis resolving. Therefore, the invention can be applied to treat lithiasis.

Description

technical field [0001] The invention relates to the application of p-hydroxyacetophenone and its derivatives in the pharmaceutical field, in particular to the application of p-hydroxyacetophenone and its derivatives in the preparation of medicaments for treating cholelithiasis. Background technique [0002] Cholelithiasis is a common disease that affects human health. The incidence in most western countries is similar, and the incidence in adults is about 10-20%. It is about 10% in our country. Female patients are about twice as common as male patients. The onset characteristics of this disease are not only age, gender, occupation, obesity and regional differences, but also environmental and genetic differences. Acquired factors, such as drugs, endotoxins, infections (including parasitic infections), hormones, biliary obstruction, liver transplantation, etc. will increase the incidence of cholelithiasis. [0003] Gallstones can be divided into cholesterol stones, pigment ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K31/137A61K31/455A61P1/16
Inventor 季申陈静刘全海贺兴冬顾性初张荣华王柯毛秀红赵帅徐智儒
Owner SHANGHAI INST OF PHARMA IND CO LTD
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