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Cosmetic compositions containing sophora alopecuroides l. extracts

A composition and extract technology, applied in other skin fields of solvent extracts, can solve the problems of low efficacy side effects, toxic skin, irritation, etc., and achieve the effect of low cost and high effect

Inactive Publication Date: 2008-01-16
UNILEVER NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, currently established substances are either less potent or have undesired side effects such as toxicity or skin irritation

Method used

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  • Cosmetic compositions containing sophora alopecuroides l. extracts
  • Cosmetic compositions containing sophora alopecuroides l. extracts
  • Cosmetic compositions containing sophora alopecuroides l. extracts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] This example illustrates the in vitro tyrosinase inhibitory activity of the Sophora alopecia plant extract of the present invention.

[0073] Raw roots collected in Dingbian County, Shaanxi Province, China through Xinzheng (Xinzheng, a local institution dealing in raw materials for traditional Chinese medicine) were used.

[0074] The extract of Sophora sophora used in the following examples was prepared according to the method described above, ie a concentrated extract.

[0075] method

[0076] MelanoDerm tissue model method:

[0077] Using the MelanoDerm tissue equivalent model (MatTek TM MEL-300). MelanoDerm cultured according to supplier requirements.

[0078] The medium was replaced every two days for 14 days, and the treatment consisted of adding natural extracts to the medium phase at a final concentration of 50-100 μg / ml. A positive control group was used, namely kojic acid and hydroquinone, which are known skin lightening agents. During each change of ...

Embodiment 2

[0088] A concentrated extract of Sophora alopecuroides was analyzed by mass spectrometry and NMR spectroscopy to identify the following compounds as described below:

[0089] 1: Sophoraflavone I

[0090] 2: Bitterone B

[0091] 3: Bitudinone A

[0092] 4: Sophoraflavone G

[0093] 5: Sophoraflavone K

[0094] 1: Sophoraflavone I (KGC-I)

[0095]

[0096] 2. Bitterone B

[0097]

[0098] 3. Bitterone A

[0099]

[0100] 4. Sophoraflavone G

[0101]

[0102] 5. Sophoraflavone K

[0103]

Embodiment 3

[0105] Cosmetic compositions within the scope of the present invention are prepared.

[0106] The base formulation in Table 3 was prepared by heating the Phase A components to 70-85°C with stirring. In a separate vessel heat the Phase B components to 70-85°C with stirring. Phase A was then added to Phase B with both phases maintained at 70-85°C. The mixture was stirred at 70-85°C for at least 15 minutes and then cooled.

[0107] table 3

[0108]

[0109] * BAL means margin.

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PUM

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Abstract

Disclosed are extracts of Sophora alopecuroides L. as cosmetic skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle. Also disclosed are active ingredients in the extracts, including alopecurone A, alopecurone B, sophoraflavone-G, sophoraflavone-I, sophoraflavone-K, and mixtures thereof. The inventive extracts, compositions and methods have effective skin lightening properties, may be easier to deliver to the skin and are available in nature.

Description

[0001] Technical Field of the Invention [0002] The present application relates to compositions for topical application to human skin, said compositions containing Sophora Alopecuroides extract, and methods of using said compositions for skin lightening. Background of the invention [0003] Many people are concerned about the degree of skin pigmentation. For example, people with age spots and freckles may want the pigmented spots to be less noticeable. Others wish to reduce the darkening of skin color caused by sun exposure or to brighten their natural complexion. In order to meet these needs, attempts have been made to develop products that reduce pigment production in melanocytes. However, currently established substances are either less potent or have undesired side effects, such as toxicity or skin irritation. [0004] Therefore, there remains a need for new skin lightening agents with improved overall effect. And, more consumers are seeking natural ingredients for sk...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97
CPCA61K36/489A61K8/97A61Q19/02A61K8/9789A61K2300/00A61K8/35A61K8/365A61K8/498A61Q17/04
Inventor B·哈里基安邹敏亮王红强
Owner UNILEVER NV
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