Solanesyl polyamine derivative, preparation and application thereof

Abstract

The invention discloses solanesyl polyamines derivatives which are compounds with the following common structural formula, wherein, n is equal to 0-2, Ar is phenyl, substitutive phenyl, 1-naphthyl, 2-naphthyl, 9-anthryl or tricyclic aryl containing N,S atoms. The preparation method is as follows: dissolve N-solanesyl-N amine alkyl piperazine in organic solvent; add aromatic aldehyde and make the mixture react for 2-24 hours under the temperature of 0-20 DEG C; steam the mixture to get rid of the solvent and then add reducer when bathing the mixture in ice water and let the mixture react for 2-12 hours under room temperature; process the products and separate the products by column chromatography to get the solanesyl polyamines derivative. The invention provides a series of new solanesyl polyamines derivatives which are the homologous derivatives of natural products, maintain the original all-trans stereo configuration of the solanesol unit and can be used as anti-neoplastic drugs and primer for the anti-neoplastic drugs. The preparation method of the invention is of simple operation with moderate condition and high reaction yield and with great market potential, thus is easy to beindustrialized.

Description

technical field The invention belongs to the technical field of pharmaceutical compounds, preparation and application thereof, and relates to a solanesyl polyamine derivative, preparation and application thereof. Background technique Solanesol naturally exists in tobacco leaves and potato leaves. It is a tetrasesquiterpene alcohol with nine isoprene units and is a natural polyterpene compound in all-trans stereo configuration. In the living body, it is an indispensable biosynthetic precursor of many isoprenoid complexes, isoprenyl proteins and carbohydrate compounds. And it has an important biochemical role as a component of biofilm and cells. Many derivatives obtained by structural modification based on solanesol have exact and important physiological functions. In recent years, researches on the antitumor activity of solanesol derivatives have become increasingly active. At present, there have been many reports on solanesol derivatives with different structures. However,...

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Problems solved by technology

In recent years, researches on the antitumor activity of solanesol derivatives have become increasingly active. At present, there have been many reports on solanesol derivatives with different structures. However, the antitumor activities of such derivatives have been published. Very low, cannot be used as a drug lead compound for in-depth research

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