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Traditional Chinese medicinal composition containing notoginseng and kudzuvine root and its preparation

The technology of a composition and traditional Chinese medicine is applied in the field of pharmaceutical compositions and preparations for the treatment of cardiovascular diseases, and can solve the problems of difficulty in preparing dripping pills and the like

Active Publication Date: 2007-12-12
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strict requirements of the drop pill preparation process on the matrix excipients, it is often difficult to prepare drop pills that meet the quality requirements after replacing the matrix excipients. Therefore, finding a suitable matrix excipient to replace the current polyethylene glycol has become a constant effort of medical personnel. direction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The raw materials used are 375g Panax notoginseng, 118g kudzu root, 4.5g balsamic oil, and 80g ginseng

[0068] Notoginseng, kudzu root and ginseng with 5 times the amount of water, decoct for 2 hours, filter, and extract the residue for the second time, add 4 times the amount of water, fry for 1 hour, filter, discard the filter residue, and combine the filtrate. The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. Add balsamic oil, dry, make granules, compress into tablets, or coat with sugar, that is to say.

Embodiment 2

[0070] Panax notoginseng 465g, kudzu root 30g.

[0071] Radix Puerariae is extracted with 70% ethanol, and the extract is micro-filtered with a ceramic membrane to collect the filtrate; The inlet pressure is 0.20kPa lower. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m / s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating or unstable flows in the membrane channel. The difference in flow rate fluctuations is 2.0m / s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 40°C. When the original feed liquid is concentrated by 1 / 8, add water or dilute alcohol so...

Embodiment 3

[0074] 485g of raw materials Panax notoginseng, 30g of kudzu root, 100g of angelica, 2.2g of borneol.

[0075] Add 5 times the amount of water to the kudzu root and angelica, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter, discard the filter residue, and combine the filtrate. The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. The crushed notoginseng, extract and borneol are fluidized with lactose in a batch fluidized bed, dried, and made into granules.

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Abstract

The invention discloses a Chinese medicinal composition for treating cardiovascular disease. the composition is mainly prepared from radix notoginseng, radix puerariae as raw material; also can further comprises Angelica sinensis or Herba Leonuri or Astragalus membranaceus or ginseng or radix codonopsis; and can also comprises borneol or Dalbergia odorifera oil or styrax or musk or musk ketone in any of the formula. The invention also discloses a preparation with any of the aforesaid Chinese medicinal composition as effective ingredient, preferably dripping pill. Its dripping pill substrate adjuvant can be polyethylene glycol or plant original substrate adjuvant. The inventive medicament has rapid action, and good therapeutic action in treating angina pectoris of coronary heart disease.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular diseases and a preparation thereof, in particular to a pharmaceutical composition for treating cardiovascular diseases which is made from traditional Chinese medicinal materials. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural areas or cities. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth respectively among the causes of death in my country, and rose to second and third respectively after 1970. Cardiovascular and cerebrovascular diseases accounted for the first of all causes of death. In my country, the proportion of deaths due to cardiovascular and cerebrovascular diseases to the total death population has risen from 12.07% in 1957 to 42.6% in 2001, and 2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K9/20A61K47/36A61P9/10A61K31/045A61K31/122A61K35/55
Inventor 李旭郑永锋白雨
Owner TIANJIN TASLY PHARMA CO LTD
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