Quinoxaline acquired by heavy ion beam irradiation effect

Abstract

The present invention is heavy ion beam irradiation effect to obtain quinhydroxy ketone, and relates to heavy ion beam irradiation technology. Heavy ion beam irradiation process for developing new medicine is superior to available chemical synthesis process, which has long developing period, high cost and high manpower consumption, and can obtain new matter in short period and separate out lead compound with obvious medicine effect. The heavy ion beam irradiation process of obtaining quinhydroxy ketone is to irradiate quinalkenyl ketone with 16O8+ and 12C6+ heavy ions in the initial energy of 75 MeV / micron, and energy depositions of 1.585x10<2> Gy-1.585x10<12>Gy and 1.656x10 Gy-1.656x10<9>Gy. The irradiation product quinhydroxy ketone has strengthened antibacterial activity and lowered toxicity, and the present invention provides one effective way for developing new medicines.

Description

technical field [0001] The invention relates to the field of radiation technology, especially the heavy ion beam radiation technology. Background technique [0002] Since Haddalin and Issidorides of Beirut, Lebanon published the first article on the Beirut reaction in 1965, hundreds of patents using this reaction have been published and no less than a thousand new N, N-diazepine- 1,4 Dioxide (quinoxaline) compounds. In fact, substituted derivatives of various quinoxaline compounds synthesized according to the Beirut reaction, such as Catbadox, Quinocetone, Mequin, etc., are used as antibacterial and growth-promoting agents in animal husbandry, veterinary medicine and aquaculture. , has achieved huge economic and social benefits. However, such compounds have relatively large toxic and side effects, and simply changing their side chains cannot meet the needs, because the result is often that the toxicity is reduced and the effect is also greatly reduced. [0003] It is an e...

AI Technical Summary

Problems solved by technology

What we plan to use is the medium-energy heavy ion beam provided by Lanzhou Heavy Ion Research Facility (HIRFL), which can irradiate thicker solid drug samples. Similar work has not been reported at home and abroad.

However, conventional radiation (such as X-, γ-rays) has been studied abroad to modify the molecular structure of organic compounds. However, the LET (ie, the energy transferred per unit distance) of conventional radiation is much smaller than that of heavy ions, and this Radiation particles are unlikely to participate in displacement or addition reactions, which make molecular structure changes less efficient

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