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Medicine composition containing theocin-like medicines and vitamin K

A composition and vitamin technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, active ingredients of hydroxyl compounds, etc., can solve the problem of difficulty in mastering the dosage of clinical drugs

Active Publication Date: 2007-11-14
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Difficult to grasp the clinical dosage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] a vitamin k1 6g

[0018] Lactose 30g

[0019] Dry starch 55g

[0020] Sodium carboxymethyl starch 30g

[0021] 12% PVP absolute ethanol solution 150g

[0022] Magnesium Stearate 2g

[0023] Preparation process: pass lactose, sodium carboxymethyl starch, and dry starch through an 80-mesh sieve, weigh the prescribed amount of vitamin K1, dissolve it in an appropriate amount of absolute ethanol, and mix evenly with the prescribed amount of lactose, sodium carboxymethyl starch, and dry starch , adding an appropriate amount of 12% PVP absolute ethanol solution to granulate, drying at 60°C, sieving the dry granules with a 16-mesh sieve, and adding a prescribed amount of magnesium stearate to the dry granules.

[0024] b aminophylline 150g

[0025] Hydroxypropyl Cellulose 65g

[0026] 10g pregelatinized starch

[0027] 6% PVP in absolute ethanol solution 30g

[0028] Magnesium Stearate 2g

[0029] Preparation process: Aminophylline is passed through a 100 mesh sieve, ...

Embodiment 2

[0032] a. Vitamin K3 3g

[0033] Hydroxypropyl Methyl Cellulose-4M 40g

[0034] Microcrystalline Cellulose 30g

[0035] 6% PVP in absolute ethanol solution

[0036] Magnesium stearate 2g

[0037] Preparation process: Vitamin K3 is passed through a 100-mesh sieve, hydroxypropyl cellulose-4M and microcrystalline cellulose are passed through a 80-mesh sieve, and the prescribed amount of vitamin K3, hydroxypropyl cellulose-4M and microcrystalline cellulose are mixed evenly, Add an appropriate amount of 6% PVP absolute ethanol solution to granulate, dry at 60°C, sieve the dry granules with a 16-mesh sieve, and add the prescribed amount of magnesium stearate to the dry granules.

[0038] b. Diprophylline 150g

[0039] Lactose 20g

[0040] Sodium Carboxymethyl Cellulose 60g

[0041] 6% PVP in 95% ethanol solution

[0042] Magnesium stearate 2g

[0043] Preparation process: dyprophylline is passed through a 100-mesh sieve, sodium carboxymethylcellulose and lactose are passed thr...

Embodiment 3

[0046] a Hydroxyprophylline 50g

[0047] Lactose 30g

[0048] Hydroxypropyl Methyl Cellulose-15M 20g

[0049] 6% PVP in 95% ethanol solution 150g

[0050] Glyceryl Behenate 2g

[0051] Preparation process: hydroxyprophylline is passed through a 100-mesh sieve, lactose and hydroxypropyl methylcellulose-15M are passed through a 80-mesh sieve, and the prescribed amount of hydroxyprophylline is mixed with lactose and hydroxypropyl methylcellulose-15M Uniformly add 6% PVP in 95% ethanol solution to granulate in an appropriate amount, dry at 60°C, sieve the dry granules with a 16-mesh sieve, and add the prescribed amount of glyceryl behenic acid into the dry granules.

[0052] b. Vitamin K2 5g

[0053] Hydroxypropyl Cellulose 15g

[0054] Dextrin 20g

[0055] 6% PVP in 95% ethanol solution 50g

[0056] Talc powder 2g

[0057] Preparation process: Vitamin K2 is passed through a 100-mesh sieve, hydroxypropyl cellulose and dextrin are passed through a 80-mesh sieve, the prescri...

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PUM

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Abstract

The present invention relates to a medicine composition containing theophyllines medicine and vitamin K for effectively curing respiratory diseases of asthma and chronic obstructive disease of lung, etc. Said medicine composition can be made into various different dosage forms.

Description

technical field [0001] The invention belongs to a new pharmaceutical composition for treating respiratory diseases. Background technique [0002] Asthma is a common respiratory disease, and its incidence is increasing year by year. The pathogenesis of asthma is very complex and has not been fully understood yet. In the 1950s, it was considered as an abnormal disease of airway smooth muscle function. In the early 1980s, it was proposed that the essence of asthma is airway hyperresponsiveness. Asthma is currently considered to be a chronic inflammatory disease of the airways involving a variety of cells and cellular components, characterized by reversible airflow obstruction in the lungs, airway mucosal inflammation, and airway hyperresponsiveness. [0003] Recent studies have also shown that long-term chronic inflammation in asthmatic patients can lead to airway remodeling, resulting in decreased pulmonary ventilation function, which can easily induce severe asthma attacks....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/122A61K31/05A61K9/20A61K9/48A61K47/38A61P11/06
Inventor 赵志全
Owner LUNAN HOPE PHARM CO LTD
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