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Soft capsule and preparing method thereof

A technology of soft capsules and rubber skins, which is applied in capsule delivery, pharmaceutical formulations, drug delivery, etc. It can solve the problems of easy aging, aging and hardening of rubber skins, and affecting disintegration speed, so as to achieve anti-aging, fast disintegration speed, and solution speed effect

Inactive Publication Date: 2007-11-14
广东富味健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But as the rubber of soft capsules, gelatin is basically used as the main gelling agent at present, and because gelatin itself has the characteristics of easy aging, the rubber is easy to age and harden, which affects the disintegration speed; and gelatin is an animal material. Many consumers of health care products, food and medicine do not like to take gelatin products, which restricts the popularization and application of soft capsule products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] First, prepare the following raw materials (the amount of each raw material is calculated without water): 90 grams of pullulan, 1.2 grams of agar, 15 grams of glycerin, 1 gram of paraffin, 2 grams of apple green pigment, 880.8 grams of apple seed oil; gram for dissolving agar and pullulan.

[0023] Then, soft capsules are prepared according to the following steps:

[0024] (1) Under the condition of stirring, soak the agar in water, the weight of the water is 310 grams (3.4 times the total weight of the plant gelling agent and pullulan polysaccharide), and the water temperature is controlled at 30-45°C; then heat to boiling , kept for 10 minutes to obtain glue;

[0025] (2) In the case of stirring, add the pullulan to the above glue, and stir until completely dissolved;

[0026] (3) glycerin and apple green pigment are added in the glue solution that step (2) obtains, mix well;

[0027] (4) Send the glue solution obtained in step (3) into a molding machine for rubber...

Embodiment 2

[0036] First, prepare the following raw materials (the amount of each raw material is calculated without water): 400 grams of pullulan, 24 grams of carrageenan, 120 grams of sorbitol, 3 grams of paraffin, 5 grams of titanium dioxide, 0.5 grams of lemon yellow pigment, collagen 347.5 grams of suspension; add 1060 grams of water to dissolve carrageenan and pullulan.

[0037] Then, soft capsules are prepared according to the following steps:

[0038] (1) In the case of stirring, add carrageenan to water and soak, the weight of water is 1060 grams (2.5 times the total weight of carrageenan and pullulan), and the water temperature is controlled at 10-25 ° C; then heated to boiling, Hold for 12 minutes to obtain glue;

[0039] (2) In the case of stirring, add the pullulan to the above glue, and stir until completely dissolved;

[0040] (3) sorbitol, titanium dioxide and tartrazine are added in the glue solution that step (2) obtains, mix homogeneously;

[0041] (4) Send the glue ...

Embodiment 3

[0050] First, prepare the following raw materials (the amount of each raw material is calculated without water): 200 grams of pullulan, 12 grams of carrageenan, 50 grams of sorbitol, 1 gram of paraffin, 0.2 grams of sunset yellow pigment, 686.8 grams of deep-sea fish oil; 636 grams of water are used to dissolve carrageenan and pullulan.

[0051] Then, soft capsules are prepared according to the following steps:

[0052] (1) In the case of stirring, add carrageenan to water and soak, the weight of water is 636 grams (3 times the total weight of carrageenan and pullulan), and the water temperature is controlled at 30-40 ° C; then heated to boiling, Hold for 15 minutes to obtain glue;

[0053] (2) In the case of stirring, add the pullulan to the above glue, and stir until completely dissolved;

[0054] (3) Sorbitol and sunset yellow pigment are added in the glue solution that step (2) obtains, mix well;

[0055] (4) Send the glue solution obtained in step (3) into the molding ...

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Abstract

The present invention provides a soft capsule and its preparation method. The composition of said soft capsule includes (by wt%) 8-45% of prolanpolysaccharide 0.01-2.5% of plant gelling agent, 1-15% of plasticizer, 33-89% of oil solution, 0.1-1% of paraffin wax, 0.01-1% of coloring matter and 0.9%-12% of water. Said invention also provides the concrete steps of its preparation method.

Description

technical field [0001] The invention relates to a soft capsule and a preparation method thereof. Background technique [0002] Soft capsule is a new dosage form developed in recent years in the fields of medicine, food, health care products, chemical products, etc. It is a quantitative pressure injection of oily substance or oily suspension and encapsulated in the rubber to form a sealed capsule. It has the advantages of accurate content, good uniformity and beautiful appearance. But as the rubber of soft capsules, gelatin is basically used as the main gelling agent at present, and because gelatin itself has the characteristics of easy aging, the rubber is easy to age and harden, which affects the disintegration speed; and gelatin is an animal material. Many consumers of health care products, food and medicine do not like to take gelatin products, which restricts the popularization and application of soft capsule products. Contents of the invention [0003] The technical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/34A61K47/36A61J3/07
Inventor 余少华刘谋泉
Owner 广东富味健康科技有限公司
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