System and method to compound a personalized nutritional supplement
A nutritional supplement, nutritional technology, applied in the field of nutritional supplementation of phenotype or personal preference, special genotype, can solve the problem that is no longer commercially available
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[0024] Other embodiments of the input device use any suitable means of personal identification. Various biometric readers are available and used by input devices to identify subjects. For example, fingerprints, retinal scans, and other biometric data can be used as personal data to identify a subject.
[0025]After inputting personal data via the input device 101 , the processor / controller 110 processes the inputted data and stores it in the memory / database unit 115 . Processor / controller 110 may be a programmable logic device (PLD), microcontroller, or computer, depending on the functions the processor / controller is intended to perform. The processor / controller is capable of accessing the memory / database unit components of the system to run one or more appropriate programs or algorithms to convert the provided personal data into personalized nutritional supplement recipes, and to configure personalized Description of nutritional supplements (direction). The personal data p...
Embodiment 1
[0053] Homocysteine / Methionine Metabolism: Homocysteinemia
[0054] Homocysteine / methionine metabolism has been implicated in a number of disease states. Polymorphisms of enzymes involved in these metabolic cycles can affect the homocysteine and methionine levels of an individual.
[0055] One enzyme in the above metabolic pathway is 5,10-methylenetetrahydrofolate reductase (MTHFR). A large number of mutations in the MTHFR gene have been identified. A specific variant in the MTHFR gene increases the risk of cardiovascular disease. Variant C677T produces a form of MTHFR with reduced activity at higher temperatures. Mutations in MTHFR typically disrupt or eliminate the activity of methylenetetrahydrofolate reductase. Methylenetetrahydrofolate reductase is required to convert homocysteine to methionine. In individuals with certain allelic forms of MTHFR, homocysteine accumulates while methionine is decreased. Numerous studies have shown that supplementation with ...
Embodiment 2
[0059] Mutagens and Toxins
[0060] Glutathione S-transferase (GST) catalyzes the coupling of glutathione to a number of potentially mutagenic or otherwise toxic compounds, including aliphatic aromatic heterocyclic groups, epoxides and arene oxides. For example, the enzyme detoxifies carcinogenic polycyclic aromatic hydrocarbons and conjugated isothiocyanates. The GST family includes glutathione S-transferase-μ (GSTMI), glutathione S-transferase-theta (GSTTI) and glutathione S-transferase-π (GSTPI). These variants of GST can cause an increase in the mutagen in an individual. Glutathione intake does not significantly increase circulating glutathione levels in individuals. However, consumption of N-acetyl-cysteine (NAC), milk thistle (Milk Thistle), alpha-lactalbumin, turmeric (turmeric, balloon flower root) and selenium can all help increase Glutathione levels.
[0061] The superoxide dismutase (SOD) family of genes produces enzymes that remove reacti...
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