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Black and white medicinal composition for improving sleep and adjusting sleep-rhythm functions

A technology for improving sleep and composition, which is applied in the field of black and white pharmaceutical compositions, can solve the problems of no breathing inhibition, practicability, curative effect, drug economy, and no interaction, so as to prevent platelet aggregation and prevent cardiovascular and cerebrovascular diseases. disease, curative effect

Inactive Publication Date: 2007-09-05
陈彦方
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] An ideal sedative-hypnotic drug should meet the following conditions: 1) quickly induce sleep; 2) have no effect on sleep structure; 3) have no drug residual effect the next day; 4) do not affect cognitive and memory functions; 5) have no inhibition on breathing 6) long-term use without drug dependence; 7) no interaction with alcohol and other drugs
However, so far, there is no sleeping drug that fully meets the above conditions
[0005] Although the Chinese invention patent "a black and white medicinal composition for treating insomnia" (Patent No. ZL 200510093405.5) discloses and provides a technical solution to solve the above-mentioned problems, it has been proved by experiments that its practicality, curative effect, and economical efficiency of the drug are all unreliable. There are certain problems

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0042] For the preparation of pharmaceutical compositions and more particularly dosage units, the present invention further comprises a composition comprising diphenhydramine and vitamin B 6 And the preparation method of two kinds of pharmaceutical compositions of aspirin and caffeine, this method comprises a certain amount of diphenhydramine (or its pharmaceutically acceptable salt) and a certain amount of vitamin B 6 A step of mixing one or more pharmaceutical excipients to prepare a black preparation, and a step of mixing a certain amount of aspirin and a certain amount of caffeine into one or more pharmaceutical excipients to prepare a white preparation.

[0043] More recently it has become more common to prescribe pharmaceutical compositions to patients in the form of "patient packs", which contain a number of dosing units or unit doses given over different periods of treatment in a single package, usually in blister packs Other utensils used. Patient packs have an advan...

Embodiment 1

[0070] Example 1: Practical Verification

[0071] Because drugs are special commodities, they must be approved by the drug administration departments of various countries in accordance with the New Drug Evaluation and Registration Management Measures before they can be used on the market, and new drugs that cannot be approved cannot be used on the market and are not practical. The drug management laws of various countries define new compound preparations as: two or more active ingredients of drugs and excipients of inactive ingredients. In China and most countries in the world, 5-hydroxytryptophan and melatonin are active food additives and not medicines. Any new compound drug whose prescription contains excipients that are neither active ingredients nor inactive ingredients violates the relevant regulations of the drug administration and cannot be approved for marketing. Unapproved drugs are defined as: counterfeit drugs.

[0072] The active ingredient prescription of the b...

Embodiment 2

[0079] Embodiment 2: Pharmacoeconomic verification

[0080] The governments of various countries define the attributes of drugs as: safe, effective, economical, stable, and uniform. The so-called economy means that the price is cheap, and the price is composed of raw material cost, manufacturing cost, taxation, and profit. In general industrial products, the raw material cost accounts for 35%-50% of the price.

[0081] product name

unit

Unit price (yuan / g)

Single consumption (g / 1000 unit dose)

Cost (yuan / 1000 single dose)

Diphenhydramine hydrochloride

g

0.365

50

18.2500

Vitamin B6

g

0.165

10

1.6500

aspirin

g

0.276

50

13.8000

caffeine

g

0.210

50

10.5000

Total:

44.2000

[0082] product name

unit

Unit price (yuan / g)

Single consumption (g / 1000 unit dose)

Cost (yuan / 1000 single dose)

...

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PUM

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Abstract

A composite black-white medicine for improving sleep quality and regulating sleep rhythm is composed of a black component taken at night and containing diphenhydramine and VB6 and a white component taken in the day and containing aspirin and caffeine.

Description

technical field [0001] The invention relates to a black-and-white pharmaceutical composition, in particular to a pharmaceutical composition including diphenhydramine for improving sleep and adjusting sleep-wake rhythm. Background technique [0002] The most basic definition of insomnia refers to often not getting enough sleep, that is, lack of sleep, or sleep not deeply or well, generally showing three characteristics of initial insomnia, intermittent insomnia and terminal insomnia. Occasional insomnia doesn't matter much, and only those who can't sleep for a long time are considered to have insomnia. The incidence of insomnia is very high. According to foreign data surveys, the incidence of insomnia in the American population is 32%-35%, and Japan is 20%. There are also a large number of insomnia patients in China, especially the number of middle-aged and elderly people who suffer from insomnia. Foreign statistics show that the elderly suffer from insomnia as high as 70%....

Claims

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Application Information

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IPC IPC(8): A61K31/4415A61K31/616A61K31/522A61P25/20A61K31/138
Inventor 陈彦方汪光亮
Owner 陈彦方
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