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A drug for treating hyperthyroidism and its preparation method

A technology for thyroid function and drugs, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of high incidence of side effects, unacceptable patients, and long courses of treatment, and achieves less toxic side effects and remarkable curative effect. , outstanding curative effect

Inactive Publication Date: 2007-08-01
内蒙古复旦元和药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These two types of drugs can cause allergies, resulting in skin rashes, damage to white blood cells, lead to a decrease in white blood cells, damage to liver function and lead to elevated transaminases, and even jaundice, and the curative effect is unstable, and drug withdrawal is prone to recurrence
In addition, although the effect of radioactive iodine treatment is good, the course of treatment is long, the cost is high, the incidence of side effects is high, and it may even lead to hypothyroidism of different degrees.
When hyperthyroidism is severe, surgery can be used for treatment, but the recurrence rate is high, the safety is low, and patients are generally unacceptable

Method used

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  • A drug for treating hyperthyroidism and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: tablet

[0019] Take 200g of gentian, 200g of seabuckthorn, 100g of Prunella vulgaris, 70g of gardenia, 70g of serrata, 40g of coptis, 30g of saxifrage and 30g of Artemisia annua, add 6 times the amount of ethanol 4440g, heat and reflux extraction twice, add 70% ethanol, add 40% ethanol for the second time, 3 hours each time, filter, combine the filtrates, recover ethanol under reduced pressure, concentrate to a thick paste with a relative density of 1.25-1.30 (50°C), dry, and pulverize , add starch, dextrin, hydroxypropyl cellulose, mix evenly, granulate, dry, granulate, add talcum powder, micropowder silica gel, mix evenly, compress into tablets, coat with film, and get ready.

[0020] Specifications: 0.5g / tablet, 2 tablets at a time, 2 times a day.

Embodiment 2

[0021] Embodiment 2: Granules

[0022] Take gentian 800g, seabuckthorn 800g, Prunella vulgaris 500g, Gardenia 250g, Serpentine 250g, Coptidis 140g, saxifrage 130g and Artemisia annua 130g, add 12 times the amount of ethanol 36000g, heat and reflux extraction twice, the first time add 95% ethanol, add 70% ethanol for the second time, each time for 2 hours, filter, combine the filtrates, recover ethanol under reduced pressure, concentrate to a thick paste with a relative density of 1.25-1.30 (50°C), dry, and pulverize , add appropriate amount of starch, dextrin, and hydroxypropyl cellulose, mix evenly, granulate, dry, granulate, pack, and get ready.

Embodiment 3

[0023] Embodiment 3: capsules

[0024] Take gentian 400g, seabuckthorn 400g, Prunella vulgaris 250g, Gardenia 125g, Serpentine 125g, Coptis chinensis 70g, saxifrage 65g and Artemisia annua 65g, add 8 times the amount of ethanol 12000g, heat and reflux extraction twice, add 90% ethanol, add 50% ethanol for the second time, extract for 2 hours each time, filter, combine the filtrates, recover ethanol under reduced pressure, concentrate to a thick paste with a relative density of 1.25-1.30 (50°C), dry, Pulverize, add appropriate amount of starch, dextrin, and hydroxypropyl cellulose, mix evenly, granulate, dry, granulate, pack into capsules, and obtain.

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Abstract

The invention relates to a medicinal preparation for treating thyroid gland hyperfunction and process for its preparation, wherein raw materials include (by weight proportion) rough gentian, seabuckthorn fruit, selfheal and cape jasmine.

Description

Technical field: [0001] The invention relates to a medicine for treating hyperthyroidism and a preparation method thereof, belonging to the field of Mongolian medicine. Background technique: [0002] Hyperthyroidism (hyperthyroidism) is a common endocrine disease. At present, Western medicine treatment of hyperthyroidism adopts drug therapy and surgical therapy. Drug therapy uses thiourea drugs, one class is thiouracil, including methylthiouracil and propylthiouracil; the other is imidazoles, including methimazole, also known as methylthioimidazole and Hyperthyroidism. These two types of drugs can cause allergies, resulting in skin rashes, damage to white blood cells, leading to a decrease in white blood cells, damage to liver function, leading to elevated transaminases, and even jaundice. In addition, although radioactive iodine therapy has a good effect, the course of treatment is long, the cost is high, the incidence of side effects is high, and it may even lead to hyp...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P5/16
Inventor 佟汇海温爱平乌苏日乐特刘斌韩春凤赵磊
Owner 内蒙古复旦元和药业有限公司
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