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Medicine composition for treating acute and chronic rhinitis or sinusitis and its preparation method

A technology for acute and chronic rhinitis and composition, applied in the field of pharmaceutical composition and preparation thereof, can solve problems such as untimely or incomplete treatment, aggravation of the disease, influence on learning, etc., and achieves improvement of Chinese medicine symptoms and Western medicine signs, good curative effect, and improved consumption. handy effect

Active Publication Date: 2007-08-01
太极集团重庆桐君阁药厂有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Acute and chronic rhinitis or sinusitis is a common and frequently-occurring disease. If the treatment is not timely or thorough, it will easily lead to aggravation of the disease. In severe cases, it will lead to loss of sense of smell, memory loss, headache and other symptoms, which will affect study and work.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0029] Experimental example 1 The effect of the oral liquid of the pharmaceutical composition of the present invention on xylene-induced mouse ear swelling:

[0030] 40 mice with a body weight of 20 ± 2g, half male and half male, are randomly divided into four groups, 10 in every group; the drug group is fed with 1.0, 2.0g / kg of this pharmaceutical composition oral liquid, and the positive control group is fed with strong Pine tablet 5 mg / kg; the normal control group was given distilled water of corresponding volume, administered once a day, for three consecutive days, 30 minutes after the last administration, smeared xylene 0.02ml / on the right ear of each mouse, and killed the mice after 15 minutes. Cut off both ears along the auricle line, take the weight difference between the two ears as the degree of swelling, and use the t value to statistically significant, the results are shown in Table 1:

[0031] Table 1 The effect of the pharmaceutical composition oral liquid of the...

experiment example 2

[0034] Experimental Example 2 The effect of the oral liquid of the pharmaceutical composition of the present invention on the permeability of mouse ear capillaries caused by xylene:

[0035] 40 mice with a body weight of 20 ± 2g, half male and half male, were equally divided into four groups, 10 in every group; the drug group was fed with oral liquid of this pharmaceutical composition 1.0, 2.0g / kg, and the positive control group was fed with prednisone Tablet 5mg / kg, the control group was fed with distilled water, administered once a day, for three consecutive days, 30min after the last administration, every mouse tail vein injection of 0.5% Evans blue normal saline, 0.2ml / 10g mice, and then in each mouse Apply 0.02ml of xylene to the right ear, kill the mouse 15 minutes later, cut off the right ear and cut it into pieces, put it in a stoppered test tube filled with 4ml of acetone; 7:3 normal saline, soak for 96 hours and pour out the supernatant The solution was colorimetric ...

experiment example 3

[0038] Experimental Example 3 The effect of the oral liquid of the pharmaceutical composition of the present invention on the swelling of the paws of rats caused by formaldehyde:

[0039] Select 40 rats with a body weight of about 180-200g, male and female, and divide them into four groups at random, with 10 rats in each group; the drug group is fed with this medicinal composition oral liquid 1.0, 2.0g / kg and administered twice a day, continuously Administration for three days, the positive control group was fed with prednisone tablets 0.025g / kg once a day × 3d, and the control group was fed with distilled water; 1 hour after the last administration, subcutaneously inject 1% formaldehyde 0.1ml in the left hind foot of each mouse After the inflammation was induced, the drug was administered once a day, and then the thickness of the paw swelling was measured at 1, 2, 4, 6, 26, 48, and 72 with a special transparent soft ruler, and compared with the normal value before injection of f...

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PUM

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Abstract

The invention relates to a Chinese compound preparation for treating acute and chronic rhinitis and nasal sinusitis and process for preparation, wherein the medicinal composition comprises magnolia flower, Schizonepeta tenuifolia, mentha, root of ballon flower, Bupleurum root, siberian cocklebur fruit, dahurian angelica root, Ligusticum wallichii, baikal skullcap root, cape jasmine, poria cocos, clematis stem, astragalus root and gentian root.

Description

field of invention [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating acute and chronic rhinitis and sinusitis and a preparation method thereof. Background technique [0002] Acute and chronic rhinitis or sinusitis is a common and frequently-occurring disease. If it is not treated in time or thoroughly, it will easily lead to aggravation of the disease. In severe cases, it will lead to loss of sense of smell, memory loss, headache and other symptoms, which will affect study and work. Scholars at home and abroad generally believe that the inflammation of the nasal cavity is mainly caused by the infection of anaerobic and aerobic bacteria; acute and chronic rhinitis and sinusitis belong to the category of "biyuan" in traditional Chinese medicine, and their pathogenesis is mostly caused by wind-heat attacking the lungs or gallbladder heat. Violation, evil heat fumigation, scor...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/08A61K9/10A61K9/16A61K9/19A61K9/20A61K9/48A61P11/02
Inventor 熊大经杨秀璐王燕华甘在誌刘新赵世望
Owner 太极集团重庆桐君阁药厂有限公司
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