Production tech. of acid type lovastatin and production tech of its salt and pharmaceutical application
A technology of lovastatin and production process, which is applied in the field of production process of acid lovastatin and acid lovastatin salt, which can solve the problems of toxic side effects, muscle pain, elevated transaminase, liver damage, etc., and avoid toxic and side effects , the effect of increasing the burden on the liver
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment Construction
[0006] The preparation method of lovastatin acid: use 95% ethanol and NaOH (100:8 ~ 13 ie m 内酯结构 :m NaOH ) to make an alkaline solution, dissolve the lactone lovastatin powder in the solution, and bathe in a water bath at 50-75°C for 30 minutes. After the water bath is completed, measure the pH value with a pH meter (usually pH10-14), Adjust the PH value so that it is between PH7.5-9.0, control the temperature at 50-75°C, and distill under reduced pressure at a pressure of -0.08MP to evaporate most of the ethanol, and then adjust the pH of the mother liquor to make it PH as Between 4.0-6.8, continue to distill under reduced pressure to obtain a concentrated solution, and then use solvent and anhydrous CaCl 2 Acid lovastatin (namely monacolin K, lovastatin) with a concentration of more than 90% is obtained through extraction.
[0007] The preparation method of acid lovastatin salt: adopt 95% ethanol and NaOH (100:8~13 namely m 内酯结构 :m NaOH ) to make an alkaline solution, di...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com