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O-phthalic aldehyde antiseptic sterilization agent and its preparation method

An ortho-phthalaldehyde and sterilant technology, applied in the field of chemistry, can solve the problems of irritation of skin and mucous membranes, unsatisfactory spore killing effect, poor stability, etc., achieving no irritating odor, fast and efficient killing, Low corrosive effect

Inactive Publication Date: 2007-07-18
GUANGDONG HUANKAI MICROBIAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, glutaraldehyde has disadvantages such as moderate toxicity, long action time (10 hours for medical device sterilization), irritation to skin and mucous membranes, strong odor, poor stability, strong influence by organic matter, and inconvenient use.
Chlorine dioxide is currently the latest generation of highly efficient, broad-spectrum, fast and safe disinfectant recognized internationally. However, chlorine dioxide is highly corrosive to metals and is only suitable for disinfection of general medical devices, and it has binary stability. Chlorine dioxide needs to be activated when used
Domestic literature has also reported many studies on the killing of bacterial spores by o-phthalaldehyde compound, but the effect of killing spores is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Add 5.5kg of o-phthalaldehyde and 30kg of absolute alcohol into a stainless steel mixing bucket, turn on the stirring blade, and stir for 30 minutes.

[0027] (2) Add 945.7kg of pure water, 6kg of ammonium chloride, 5kg of octadecyltrimethylammonium chloride, 4kg of fatty alcohol polyoxyethylene ether, and 3kg of Tween-80 into a stainless steel mixing tank, and stir for 60 minutes .

[0028] (3) Add 0.8 kg of sodium hydroxide to adjust the pH of the solution to 7-8, stir for 15 minutes and then filter with a 400-mesh filter cloth, collect the filtrate to prepare 1000 kg of o-phthalaldehyde disinfectant.

[0029] (4) Turn on the vacuum pump and pump the disinfectant in the stainless steel mixing tank into the stainless steel storage tank for filling.

Embodiment 2

[0031] (1) Add 6.0kg of o-phthalaldehyde and 40kg of absolute alcohol into a stainless steel mixing bucket, turn on the stirring blade, and stir for 30 minutes.

[0032] (2) Add 928kg of pure water, 10kg of ammonium chloride, 8kg of benzalkonium bromide, 2kg of fatty alcohol polyoxyethylene ether, and 5kg of Tween-80 into a stainless steel mixing tank, and stir for 60 minutes in an airtight manner.

[0033] (3) Add 1.0 kg of sodium hydroxide to adjust the pH to 9-10, stir for 15 minutes and filter with a 400-mesh filter cloth, collect the filtrate to prepare 1000 kg of o-phthalaldehyde disinfectant.

[0034] (4) Turn on the vacuum pump and pump the disinfectant in the stainless steel mixing tank into the stainless steel storage tank for filling.

Embodiment 3

[0036] (1) Take 5kg of o-phthalaldehyde and 50kg of absolute alcohol and put them into a stainless steel mixing bucket, turn on the stirring blade, and stir for 30 minutes.

[0037] (2) Add 911.5kg of pure water, 15kg of ammonium chloride, 10kg of betaine, 3kg of fatty alcohol polyoxyethylene ether, and 4kg of Tween-80 into a stainless steel mixing tank, and stir for 60 minutes in an airtight manner.

[0038] (3) Add 1.5 kg of sodium bicarbonate to adjust the pH value to 10-11, stir for 15 minutes and filter with a 400-mesh filter cloth, collect the filtrate to make 1000 kg of o-phthalaldehyde disinfectant.

[0039] (4) Turn on the vacuum pump and pump the disinfectant in the stainless steel mixing tank into the stainless steel storage tank for filling.

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PUM

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Abstract

A phthalylaldehyde sterilizer for medical apparatus is prepared from phthalylaldehyde, purified water, ammonium chloride, octadecylytrimethyl ammonium chloride or benzalkonium bromide or betaine, emtrol polyoxyvinylether and tween-80 through dissolving phthalylaldehyde crystals in absolute alcohol, sequentially adding others, stirring, adding soldium dicarbonate to regulate pH value, and filtering.

Description

【Technical field】 [0001] The invention relates to a disinfectant and sterilizer for medical instruments whose aldehyde group is directly connected to an aromatic ring system and a preparation method thereof, belonging to the field of chemistry. 【Background technique】 [0002] The disinfection and sterilization of medical devices is one of the key means to prevent and control nosocomial infections and ensure the quality of medical care. Commonly used medical device disinfection and sterilization methods include physical and chemical methods. Among them, heat-sensitive devices generally use chemical methods. The chemical disinfection and sterilization agents currently used mainly include ethylene oxide, formaldehyde, glutaraldehyde, peracetic acid, chlorine dioxide, etc. [0003] Glutaraldehyde, as the third-generation low-temperature disinfectant, is the first choice for modern medical devices, especially those that are afraid of heat and corrosion. It has the advantages of...

Claims

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Application Information

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IPC IPC(8): A61L2/18A61L101/32
Inventor 程胜中吴清平邓金花黄静阙绍辉
Owner GUANGDONG HUANKAI MICROBIAL SCI & TECH
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