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Liquid vitamic C compounded nanometer elementary selenium its preparation method and storage method

A nano-element and vitamin technology, which is applied to medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, can solve problems such as non-active ingredients and adverse effects, achieve strong health care effects, expand application scope, and low production costs. Effect

Inactive Publication Date: 2007-07-18
BEIJING BOAI XIKANG NITRITION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The preparation methods involved in the above-mentioned invention patents must use "templates" such as proteins, polypeptides, glucosinoglycans, melatonin, and mixed amino acids. These templates may not be active ingredients in some practical applications, so they may will have adverse effects

Method used

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  • Liquid vitamic C compounded nanometer elementary selenium its preparation method and storage method
  • Liquid vitamic C compounded nanometer elementary selenium its preparation method and storage method

Examples

Experimental program
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Effect test

Embodiment 1

[0015] At normal temperature and pressure (15-35°C, 1 standard atmospheric pressure), the concentration is 0.2mol L -1 Each 25ml of vitamin C solution was added to five 50ml volumetric flasks respectively, and the concentration of each dropwise addition was 4×10 -4 mol L -1 0.5, 1, 2, 4, 8ml of selenium dioxide solution, shake gently while adding dropwise, wait until the red color no longer changes, set the volume to 50ml, and a series of selenium concentrations of 4, 8, 16, 32, 64μmol·L -1 The product. The product can be stored in the form of sol in aqueous solution at 2-10°C.

Embodiment 2

[0017] At normal temperature and pressure, take the concentration as 0.2mol L -1 Each 25ml of vitamin C solution was added to five 50ml volumetric flasks respectively, and the concentration of each dropwise addition was 4×10 -4 mol L -1 0.5, 1, 2, 4, 8ml of sodium selenite solution, shake gently while adding dropwise, wait until the red color does not change, set the volume to 50ml, and a series of selenium concentrations of 4, 8, 16, 32 , 64 μmol L -1 The product. The product can be stored in the form of sol in aqueous solution at 2-10°C.

[0018] The particle diameter of the nano selenium particles of embodiment 1 and embodiment 2 is as table 1 (the main particle diameter refers to the particle diameter of the largest number of particles, and the particle diameter range refers to the distribution range of all particle diameters).

[0019] Table 1

[0020] Selenium concentration

Embodiment 3

[0022] At normal temperature and pressure, take the concentration as 0.2mol L -1 Each 12.5ml of vitamin C solution was added to five 50ml volumetric flasks respectively, and the concentration of each dropwise addition was 4×10 -4 mol L -1 0.5, 1, 2, 4, 8ml of selenium dioxide solution, shake gently while adding dropwise, wait until the red color no longer changes, set the volume to 50ml, and a series of selenium concentrations of 4, 8, 16, 32, 64μmol·L -1 The product. The product can be stored in the form of sol in aqueous solution at 2-10°C.

[0023] The particle size of the nano-selenium particles of Example 3 is shown in Table 2 (the main particle size refers to the particle size of the largest number of particles, and the particle size range refers to the distribution range of all particle sizes).

[0024] Table 2

[0025] Selenium concentration

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Abstract

A liquid-phase nano-Se containing VC used as a bioactive health-care product stored in liquid phase is prepared through dropping the solution of selenium oxide or selenite into VC solution while stirring until the red color is not changed. It can be used to prepare medicines.

Description

technical field [0001] The invention relates to vitamin C nano-selenium, in particular to a method for preparing and preserving liquid-phase vitamin C nano-selenium. Background technique [0002] Selenium is an essential trace element for human body. Selenium has important biological functions such as anti-oxidation, regulating immunity, and antagonizing harmful heavy metals. Selenium deficiency is related to more than 40 kinds of diseases, particularly serious ones such as AIDS, hepatitis B, liver cancer, Keshan disease, Kashin-Beck disease, and cardiovascular and cerebrovascular diseases. Appropriate selenium supplementation can effectively prevent and control related diseases. Regarding the selenium intake standard of normal people, the World Health Organization (WHO) stipulates that it is 40 μg / d to 100 μg / d, the Chinese Nutrition Society recommends that it is 60 μg / d to 200 μg / d, and Canada stipulates that it is 98 μg / d to 224 μg / d . More than 40 countries and regio...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61P3/00A61P3/02A61K31/375
Inventor 郑文杰王自白燕张俊苓杨芳周艳晖
Owner BEIJING BOAI XIKANG NITRITION TECH
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