Slow-release anticarcinogen contg. carmustine and fluorouracil
A technology of carmustine and fluorouracil, which is applied in the field of anti-cancer sustained-release agents, can solve problems such as unclear effects, and achieve the effects of facilitating drug injection, reducing toxicity, and reducing drug concentration
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0133] Put 90 mg of polylactic acid (PLA) with a molecular weight of 20,000-40,000 as a pharmaceutical excipient into a container, add 100 ml of organic solvent dichloromethane to dissolve and mix well, add 10 mg of carmustine, re-shake, and then vacuum dry to remove the organic solvent . Shake again and dry in vacuo to remove the organic solvent. Freezing and pulverizing the dried drug-containing solid composition to make a micropowder containing 10% carmustine by weight, and then suspending it in physiological saline containing 1.5% sodium carboxymethylcellulose to prepare the corresponding suspension-type slow Release injection, the viscosity is 380cp-460cp (at 25°C-30°C). The subcutaneous release time is 30-35 days.
Embodiment 2
[0135] Put 75 mg of polylactic acid (PLGA, 50:50) with a molecular weight of 30,000-50,000 pharmaceutical excipients into a container, add 100 ml of organic solvent dichloromethane to dissolve and mix, add 25 mg of carmustine, re-shake and vacuum Dry to remove organic solvent. The dried solid composition is shaped immediately, subpackaged and then sterilized by radiation to obtain an anticancer in vivo implant containing 25% by weight carmustine for treating solid tumors. The subcutaneous release time is 35-40 days.
Embodiment 3
[0137] Put 90 mg of pharmaceutical excipient polyphenylpropane (p-carboxyphenylpropane: sebacic acid weight ratio is 50:50) into the container, add 100 ml of organic solvent dichloromethane to dissolve and mix, add 10 mg of carmustine , shake again and dry in vacuo to remove the organic solvent. The dried solid composition is shaped immediately, subpackaged and then sterilized by radiation to obtain an anticancer in vivo implant containing 10% carmustine by weight for treating solid tumors. The subcutaneous release time is 15-20 days.
PUM
Property | Measurement | Unit |
---|---|---|
Viscosity | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com