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Method for extracting 6-O-coffee acylarbutin

A technique for caffeoyl arbutin and an extraction method, which is applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve problems such as unreported extraction of arbutin, and achieve stable content, high content, The effect of low production cost

Inactive Publication Date: 2010-01-06
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Relevant documents also reported the fermentation extraction process of arbutin, but the method for extracting arbutin from plants has not been reported yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 20Kg of the whole plant of Yunnan bilberry plant (branches and leaves, tender buds, bark and roots), grind it to coarse powder, add 150 L of 50% (volume concentration) ethanol aqueous solution to reflux and extract three times, combine the extracts, reclaim ethanol, and obtain a wet extract About 12Kg, specific gravity about 1.15.

[0017] Dissolve the above wet extract with 50Kg hot water at 90°C, and keep it at about 80°C, separate it by membrane filtration, collect the filtrate, cool it, and let it stand overnight, vaccinin crystals precipitate, collect the crystals by filtration, and obtain 6-O-coffee Acyl arbutin crude product 3.5Kg.

[0018] Dissolve the above crude product of bilcincin in 20L aqueous ethanol (60%), add 250g of active carbon for decolorization, filter and recover ethanol, cool and crystallize to obtain qualified 6-O-caffeoylarbutin 2.1Kg, content 81%.

Embodiment 2

[0020] Take 20Kg of young buds of Vaccinium yunnanensis plant, crush them into coarse powder, add 150L of 70% ethanol aqueous solution to reflux and extract three times, combine the extracts, recover ethanol, and obtain about 14Kg of wet extract, with a specific gravity of about 1.13.

[0021] Dissolve the above wet extract with 50Kg hot water at 90°C, and keep it at about 80°C, separate it by membrane filtration, collect the filtrate, cool it, and let it stand overnight, vaccinin crystals precipitate, collect the crystals by filtration, and obtain 6-O-coffee Acyl arbutin crude product 4.5Kg.

[0022] Dissolve the above crude product of bilcincin in 20L aqueous ethanol (80%), add 250g of activated carbon for decolorization, filter and recover ethanol, cool and crystallize to obtain 3.0Kg of qualified 6-O-caffeoylarbutin with a content of 89%.

Embodiment 3

[0024] Get 20Kg of bilberry (paofanhua) plant branches and leaves, grind to coarse powder, add 250L of 60% ethanol aqueous solution to reflux and extract three times, combine the extracts, reclaim ethanol, and obtain about 10Kg of wet extract, with a specific gravity of about 1.13.

[0025] Dissolve the above wet extract with 40Kg hot water, keep it at about 90°C, separate it by membrane filtration, discard the retained liquid, collect the filtrate, cool it, and place it overnight, the crystals of vaccinin crystallize out, collect the crystals by filtration, and obtain 6- O-caffeoyl arbutin crude product 3.7Kg.

[0026] Dissolve the above crude product of bilcincin in 20L aqueous ethanol (80%), add 250g of activated carbon for decolorization, filter and recover ethanol, cool and crystallize to obtain 2.9Kg of qualified 6-O-caffeoylarbutin with a content of 75%.

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PUM

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Abstract

The invention relates to a method for extracting arbutin, expecially extraction from plants. It comprises following steps: (1) disintegrating platycodon glaucus plants to coarse powder, adding 50- 90% (volumetric concentration) water- containing ethanol with its weight being 4- 10 times of that of plants, refluxing and extracting, combining with extract liquor, recovering ethanol, getting wet concrete; (2) adding hot water with its weight being 2- 5 times of that of wet concrete for disslovation, filtering at 60- 80 Deg. C with membrane, collecting filter liquid, cooling, stewing for 24 hours, recrystallizing; (3) collecting said crystal, adding 60- 80% of water- containing ethanol for disslovation, adding active carbon for decoloring, filtering and recovering ethanol, cooling for crystallization and getting required 6- 0- coffee acyl arbutin. The invention is characterized by effective combination of steps of extraction, membrane filtering, active carbon decoloring and recrystallization with material, high extract rate, high content and stability and low production.

Description

technical field [0001] The invention relates to a method for extracting arbutin, especially a method for extracting from plants. technical background [0002] The efficacy and role of arbutin are increasingly recognized by the public, and its application fields are becoming more and more extensive. Chinese patent CN200510027958.0 discloses "a preparation method of α-arbutin", which is characterized in that the main steps of the preparation method are: firstly, under the condition of the presence of inert gas, the active sugar donor 2 , 3,4,6-Tetra-O-benzyl-1-O-α-D-glucosyl trichloroacetimide ester was dissolved in a solvent and reacted with hydroquinone at -100°C under Lewis acid catalysis Carry out glycosylation at ~35°C to obtain the intermediate 4-hydroxyphenyl-2',3',4',6'-tetra-O-benzyl-1'-O-α-D-glucopyranoside , and then hydrogenolysis the obtained intermediate 4-hydroxyphenyl-2',3',4',6'-tetra-O-benzyl-1'-O-α-D-glucopyranoside to obtain target product. Relevant doc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/203C07H1/08
Inventor 赵守仁罗福顺王丽娜
Owner YUNNAN BAIYAO GROUP
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