Aromatic turmeric oil nano emulsion and its preparation process

A technology of nano-emulsion and zedoary turmeric oil, applied in the directions of antiviral agents, pharmaceutical formulations, emulsion delivery, etc., can solve the problems of easy blocking of capillaries, easy stratification of emulsions, and reduced curative effect, etc., to improve the therapeutic effect and solve the physical stability. Sexuality, the effect of reducing toxic side effects and adverse reactions

Inactive Publication Date: 2009-12-23
SHANGHAI INST OF PHARMA IND CO LTD
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  • Description
  • Claims
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Problems solved by technology

The zedoary oil injection emulsion of the above-mentioned CN1562174A patent is an emulsion with an emulsion particle range of 0.5 to 5 μm, which belongs to a micron (μm) level coarse dispersion system in pharmacy, and the zedoary oil injection emulsion has certain defects as intravenous injection, such as storage During the period, the emulsion is easy to delaminate, the milk particles are enlarged, and the physical stability is poor; after intravenous injection, it is easy to block capillaries, and there is a hidden danger of embolism; the targeting effect of the micron-scale drug delivery system is mainly passive targeting, and the milk particles after intravenous injection It is mainly concentrated in the reticuloendothelial system such as the liver, and zedoary oil is mainly used clinically to treat viral influenza, upper respiratory tract infection, viral pneumonia, viral enteritis, viral myocarditis, viral encephalitis, etc., and its passive targeting On the contrary, the drug concentration in the above lesions is very low, which reduces the curative effect

Method used

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  • Aromatic turmeric oil nano emulsion and its preparation process
  • Aromatic turmeric oil nano emulsion and its preparation process
  • Aromatic turmeric oil nano emulsion and its preparation process

Examples

Experimental program
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Effect test

Embodiment 1～13

[0033] 100ml of zedoary oil nanoemulsions were respectively prepared according to the following preparation methods in Examples 1-12 in Table 1, wherein Example 13 was a comparative example.

[0034] 1. Preparation of zedoary oil colostrum: Add emulsifier and auxiliary emulsifier to an appropriate amount of solvent, stir to dissolve completely, and add different additives according to different administration routes (such as intravenous injection preparations or ophthalmic preparations) Need to add isotonic agent, non-sterile oral or external preparations need to add antibacterial agent, etc.), stir to dissolve; then, add Zedoary oil (or oil dissolved in vegetable oil) under 10000 rpm high-speed stirring solution), continue to stir for 10 minutes to form milky white colostrum, except in Example 12, adjust the pH to about 7.0 with 0.1mol / L sodium hydroxide solution, and replenish to the full amount with water.

[0035] 2. Preparation of zedoary oil nanoemulsion: transfer the ab...

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Abstract

The invention discloses a nano emulsion comprising the following components (by weight portion): rhizoma zedoariae oil 0.01-5% (g / ml), emulsifying agent 0.1-5%, auxiliary emulsifying agent 0.5-7%, and balancing solvent to 100ml. The invention also discloses the process for preparing the emulsion.

Description

technical field [0001] The invention relates to a zedoary oil emulsion, in particular to a zedoary oil nanoemulsion and a preparation method thereof. Background technique [0002] Zedoary oil is a kind of volatile oil extracted by steam distillation from the dried rhizome of Zingiberaceae plant Curcuma wenyujin Y.H.Chen et C.Ling. It has antiviral, antitumor and antithrombotic effects. Zedoary oil is listed as an antiviral drug and an antineoplastic drug. The legal preparations include Zedoary oil injection and Zedoary oil glucose infusion. Zedoary oil emulsion, zedoary oil gel, zedoary oil nanocapsule freeze-dried powder injection, zedoary oil β-cyclodextrin inclusion compound, etc. [0003] Efficacy tests have shown that turmeric oil can inhibit or directly inactivate Staphylococcus aureus, rotavirus, syncytial virus, influenza virus, hemolytic streptococcus, Escherichia coli, typhoid bacillus, and Vibrio cholerae. Curcuma oil injection is mainly used clinically as an an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K36/9066A61P31/12A61P35/00
Inventor 马晋隆陈志明卢艳萍
Owner SHANGHAI INST OF PHARMA IND CO LTD
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