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Compound preparation of Chinese traditional medicine for treating fatty liver, and preparation method

A technology of compound preparations and fatty liver, which is applied in the direction of medical formula, medical preparations containing active ingredients, pill delivery, etc. It can solve the problems of lack of fatty liver specificity, doubts about curative effect, and aggravation of fatty liver.

Active Publication Date: 2009-06-10
SHANGHAI UNIV OF T C M +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned drugs not only lack the specificity for the treatment of fatty liver, and their efficacy is questioned, but some chemically synthesized hypolipidemic drugs have short-term effects on fatty liver, but long-term use may have potential hepatotoxicity, and even aggravate fatty liver

Method used

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  • Compound preparation of Chinese traditional medicine for treating fatty liver, and preparation method
  • Compound preparation of Chinese traditional medicine for treating fatty liver, and preparation method
  • Compound preparation of Chinese traditional medicine for treating fatty liver, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Capillary chen, Polygonum cuspidatum and Turmeric are extracted three times with ethanol, each time for 1-2 hours. Gardenia and Tianjihuang adopt the extraction process of joint decoction, that is, gardenia and Tianjihuang are soaked in water for 1 hour, added 8 to 10 times of water, and extracted three times. After the water extract is concentrated to a relative density of 1.08 to 1.12 (80°C), Purification treatment is carried out, and the purification method adopts ethanol precipitation method, centrifugation method or chitosan clarification method. The above ethanol extracts of capillary, polygonum cuspidatum, and turmeric are extracted with water and other medicinal extracts that have been purified, combined and mixed, and the weight ratio of each component is: capillary wormwood 26% polygonum cuspidatum 14% Tianjihuang 14% turmeric 14% gardenia 14%, dry, and add appropriate auxiliary materials to make solid oral dosage form.

[0034] The preparation method of the ...

Embodiment 2

[0036] Capillary chen, Polygonum cuspidatum and Turmeric are extracted three times with ethanol, each time for 1-2 hours. Gardenia and Tianjihuang adopt the extraction process of joint decoction, that is, gardenia and Tianjihuang are soaked in water for 1 hour, added 8 to 10 times of water, and extracted three times. After the water extract is concentrated to a relative density of 1.08 to 1.12 (80°C), Carry out purification treatment, and the purification method can be ethanol precipitation method, centrifugation method or chitosan clarification method. The above ethanol extracts of Capillaris, Polygonum cuspidatum, and Turmeric are extracted with water and other medicinal extracts that have been purified, combined and mixed, and the weight ratio of each component is: Capillary wormwood 26% Polygonum cuspidatum 14% Tianjihuang 14% Turmeric 23% Gardenia 23%, dry, and add appropriate auxiliary materials to make a solid oral dosage form.

[0037] The preparation method of the do...

Embodiment 3

[0039] Capillary chen, Polygonum cuspidatum and Turmeric are extracted three times with ethanol, each time for 1-2 hours. Gardenia and Tianjihuang adopt the extraction process of joint decoction, that is, gardenia and Tianjihuang are soaked in water for 1 hour, added 8 to 10 times of water, and extracted three times. After the water extract is concentrated to a relative density of 1.08 to 1.12 (80°C), Carry out purification treatment, and the purification method can be ethanol precipitation method, centrifugation method or chitosan clarification method. The above ethanol extracts of capillary, polygonum cuspidatum, and turmeric are extracted with water and purified extracts of other medicinal flavors, combined and mixed, and the weight ratio of each component is: capillary 38% polygonum cuspidatum 14% Tianjihuang 14% turmeric 14 %Gardenia 14%, dry, adding appropriate auxiliary materials, made into a solid oral dosage form.

[0040]The preparation method of the dosage form can...

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Abstract

A Chinese medicine in the form of orally taken solid for treating fatty liver and fatty hepatitis is prepared from 5 Chinese-medicinal materials including oriental wormwood, giant knotwood rhizome, turmeric, capejasmine fruit, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a compound traditional Chinese medicine preparation for treating fatty liver and a preparation method thereof Background technique [0002] Fatty liver refers to a pathological state in which liver fat metabolism dysfunction caused by various reasons leads to excessive accumulation of hepatic triglycerides. It was proposed from a pathological perspective in the 1950s. According to reports in recent years, in Europe and the United States, about 20% of NASH develops into liver cirrhosis within 10 years. The recognition of the pathological relationship among fatty liver, steatohepatitis, and liver cirrhosis breaks the long-standing view that the prognosis of fatty liver is good, and the research on fatty liver is increasingly paid attention to internationally. The pathogenic factors of fatty liver are complex, currently considered to be mainly nutritional factors (such as ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K36/744A61K36/704A61K36/282A61K36/28A61K36/185A61K9/48A61K9/46A61K9/20A61K9/16A61P1/16
Inventor 刘平胡义扬张宁刘成海冯琴
Owner SHANGHAI UNIV OF T C M
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