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Improved preparation process of 8-chlorotheophylline

A chlorotheophylline and process technology, applied in the field of pharmaceutical chemical intermediates, can solve the problems of 8-chlorotheophylline, such as unsatisfactory quality, high labor intensity of workers, and harsh operating environment, so as to reduce fixed asset costs and shorten the production cycle , The effect of improving the operating environment

Active Publication Date: 2009-03-11
JILIN SHULAN SYNTHETIC PHARMA
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Problems solved by technology

[0003] The technological process of routine production 8-chlorophylline is as shown in Figure 1, is catalyst with iodine, and nitrobenzene is solvent, and caffeine and chlorine react, generate 7,8-dichlorocaffeine, and steam out nitrobenzene , hydrolysis, drying, powdering, inspection, and packaging processes to obtain finished products. In the hydrolysis process, steam and water are added, and the operating temperature is as high as 100-110 ° C. It needs to be maintained for 20 hours. There are many equipments used, the production cycle is long, and the workers are laborious. High strength, harsh operating environment, on-site temperature as high as 40-50°C, large amount of steam consumption, high production cost, and the quality of 8-chlorotheophylline is not ideal

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  • Improved preparation process of 8-chlorotheophylline
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Embodiment Construction

[0031] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0032] Taking the 8-chlorotheophylline production plant with an annual production scale of 50 tons as an example, the production process is shown in Figure 2, and the relevant production operations are as follows:

[0033] 1. The chlorination process is an existing technology;

[0034] 2. The process of steaming nitrobenzene is also a prior art;

[0035] 3. Purification process

[0036] 3.1. The material liquid after chlorination and steaming of nitrobenzene is added to the purification tank, and the proportion of the material is shown in Table 3.

[0037] table 3

[0038] raw material name Proportion (weight ratio) Feeding amount Raw material specification 7,8-Dichlorocaffeine 1 60-80kg Decomposition point above 293°C pure water 12 720-960L Clarity, transparency, no impurities

sodium hydro...

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Abstract

The invention discloses a modifying technique of 8-dimenhydrinate as intermediate in the medical and chemical domain, which comprises the following steps: chlorinating; evaporating nitrobenzene; generating and purifying 8-dimenhydrinate from 7, 8-dichlorocaffeine; adding 7, 8-dichlorocaffeine and pure water into purifying tank with weight rate at 1:(10 -15); adjusting pH value through sodium hydroxide and diluted sulfuric acid; drying; beating into powder; testing; packing; shortening manufacturing period by one time with the same equipment; improving operating environment; reducing working strength; saving steam from 20% to 9%; improving receiving rate from 62% to 65%.

Description

technical field [0001] The invention relates to a chemical intermediate for medicine. Background technique [0002] 8-Chlorophylline is a pharmaceutical and chemical intermediate, mainly used in the production of dimenhydrinate. Dimenhydrinate is also called dimenhydrinate, also called Chengyunning and haonhaining. It is a white crystalline powder. Its domestic , The foreign market prospect is good. [0003] The technological process of routine production 8-chlorophylline is as shown in Figure 1, is catalyst with iodine, and nitrobenzene is solvent, and caffeine and chlorine react, generate 7,8-dichlorocaffeine, and steam out nitrobenzene , hydrolysis, drying, powdering, inspection, and packaging processes to obtain finished products, in which steam and water are added during the hydrolysis process, and the operating temperature is as high as 100-110°C, which needs to be maintained for 20 hours. Many equipments are used, the production cycle is long, and labor is laborious....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D473/12
Inventor 郭跃民李威李立东
Owner JILIN SHULAN SYNTHETIC PHARMA
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