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Yimaikang dispersion tablet and its preparing method

A technology for dispersible tablets and Dengzhan Xixin, which is applied to the field of Yimaikang dispersible tablets and their preparation, can solve the problems of slow dissolution, long disintegration time for ordinary tablets, slow onset of effect, etc. handy effect

Inactive Publication Date: 2008-12-03
云南白药集团大理药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Yimaikang Tablets are recorded in the twelfth volume of traditional Chinese medicine prescriptions. They are ordinary tablets made of the traditional Chinese medicine Erigeron breviscapus through extraction and processing. This ordinary tablet has a long disintegration time and a slow dissolution rate, and the dissolution rate reaches 80% in 120 minutes. , resulting in slower onset

Method used

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  • Yimaikang dispersion tablet and its preparing method
  • Yimaikang dispersion tablet and its preparing method
  • Yimaikang dispersion tablet and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Erigeron extract 160g

[0053] Lactose 120g

[0054] Microcrystalline Cellulose 150g

[0055] Hypromellose (low substitution) 90g

[0056] Crospovidone 60g

[0057] Stevia 10g

[0058] 95% ethanol 100ml

[0059] Micronized silica gel 6g

[0060] Magnesium Stearate 4g

[0061]

[0062] Makes 1000 pieces

[0063] The raw and auxiliary materials were crushed through a 100-mesh sieve, and the purchased raw materials Erigeron breviscapus extract, lactose, microcrystalline cellulose, hydroxypropyl cellulose (low substitution), crospovidone (1 / 2 amount) were weighed according to the prescription amount ), stevioside, mixed evenly, adding 95% ethanol to make soft material, soft material is granulated with 18 mesh sieve, wet granule is dried at 50 ℃, after drying, granulate with 18 mesh sieve, add crospovidone (1 / 2 amount), micropowder silica gel, magnesium stearate, mix evenly, measure the content of the semi-finished product,...

Embodiment 2

[0065] Erigeron extract 80g

[0066] Lactose 50g

[0067] Microcrystalline Cellulose 50g

[0068] Hypromellose (low substitution) 20g

[0069] Crospovidone 20g

[0070] Stevia 2g

[0071] 95% ethanol 40ml

[0072] Micronized silica gel 2g

[0073] Magnesium Stearate 2g

[0074]

[0075] Makes 1000 pieces

[0076] The raw and auxiliary materials were crushed through a 100-mesh sieve, and the purchased raw materials Erigeron breviscapus extract, lactose, microcrystalline cellulose, hydroxypropyl cellulose (low substitution), crospovidone (1 / 2 amount) were weighed according to the prescription amount ), stevioside, mixed evenly, adding 95% ethanol to make soft material, soft material is granulated with 18 mesh sieve, wet granule is dried at 50 ℃, after drying, granulate with 18 mesh sieve, add crospovidone (1 / 2 quantity), micropowder silica gel, magnesium stearate, mix evenly, measure the content of the semi-finished product, press t...

Embodiment 3

[0078] Erigeron extract 160g

[0079] Lactose 200g

[0080] Microcrystalline Cellulose 250g

[0081] Hypromellose (low substitution) 150g

[0082] Crospovidone 150g

[0083] Stevia 20g

[0084] 95% ethanol 200ml

[0085] Micronized silica gel 20g

[0086] Magnesium Stearate 10g

[0087]

[0088] Makes 1000 pieces

[0089] The raw and auxiliary materials were crushed through a 100-mesh sieve, and the purchased raw materials Erigeron breviscapus extract, lactose, microcrystalline cellulose, hydroxypropyl cellulose (low substitution), crospovidone (1 / 2 amount) were weighed according to the prescription amount ), stevioside, mixed evenly, adding 95% ethanol to make soft material, soft material is granulated with 18 mesh sieve, wet granule is dried at 50 ℃, after drying, granulate with 18 mesh sieve, add crospovidone (1 / 2 amount), micropowder silica gel, magnesium stearate, mix evenly, measure the content of the semi-finished product...

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Abstract

The Yimaikang dispersion tablet consists of fleabane extractum and medicine carrier. Its recipe includes fleabane extractum, lactose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, cross-linked polyvidon, steviosin, alcohol, fine silica gel powder and magnesium stearate. The dispersion tablet can disintegrate completely in 3 min to reach homogeneous dispersive state and its effective component andrographolide has dissolving rate reaching 60 % in 10 min. It is used in treating ischemic cerebral vascular diseases, cerebral hemorrhage sequela, vein obstruction, etc. and has fast acting, good taste and convenient taking.

Description

【Technical field】 [0001] The invention relates to a new medicinal preparation of the traditional Chinese medicine Yimaikang and its formula composition, in particular to a Yimaikang dispersible tablet and a preparation method thereof. 【Background technique】 [0002] Yimaikang Tablets are recorded in the twelfth volume of traditional Chinese medicine prescriptions. They are ordinary tablets made of the traditional Chinese medicine Erigeron breviscapus through extraction and processing. The ordinary tablets disintegrate for a long time and dissolve slowly, and the dissolution rate reaches 80% in 120 minutes. , resulting in slower onset. In the present invention, Yimaikang is made into a new dosage form of dispersible tablets, so that the medicinal active ingredient Erigeron breviscapitalis extract can be quickly disintegrated and reach a uniformly dispersed state, the active ingredients can be dissolved quickly, and the taste is improved by adding flavoring agents , can be di...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/28A61P9/10A61P17/00A61P29/00
Inventor 韩渤腾健
Owner 云南白药集团大理药业有限责任公司
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