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Peony astragalus polyglucoside composition for treating liver disease and its preparation method

A composition and technology of peony root are applied in the field of pharmaceutical compositions and their preparation, which can solve the problems of lack and the like, and achieve the effects of easy quality control, good therapeutic efficacy and small effective dose.

Inactive Publication Date: 2008-05-07
魏伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no ideal safe and effective anti-hepatitis drug clinically, especially the lack of drugs for the treatment of chronic hepatitis and liver fibrosis

Method used

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  • Peony astragalus polyglucoside composition for treating liver disease and its preparation method
  • Peony astragalus polyglucoside composition for treating liver disease and its preparation method
  • Peony astragalus polyglucoside composition for treating liver disease and its preparation method

Examples

Experimental program
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Effect test

preparation example Construction

[0024] One of the preparation methods of preparation medicine:

[0025] 1. Preparation of total glucosides of paeony:

[0026] Take Radix Paeoniae Alba in proportion, and process it into common Chinese medicine decoction pieces according to Chinese Pharmacopoeia 2000 edition one: put the Radix Paeoniae Alba into alcohol-water system, the concentration of ethanol is 0-95%, and the weight ratio is Radix Paeoniae Alba: Alcohol=1:2-15, extract 2-4 times, each extraction time is 0.5-5 hours, to obtain ethanol extract; concentrate the ethanol extract under reduced pressure until there is no ethanol smell, filter, and use D101, D-3520 . solution, concentrated under reduced pressure, and dried under reduced pressure to obtain total glucosides of paeony powder.

[0027] 2. Preparation of total astragalus saponins:

[0028] Get Radix Astragali medicinal material in proportion, process it into common Chinese herbal decoction pieces according to Chinese Pharmacopoeia 2000 edition one; ...

Embodiment 1

[0068] Take 80kg of Radix Paeoniae Alba and 20kg of Radix Astragali, crush them into coarse powder, put them into an extraction tank, add 800L of water to boil for 3 times, each time for 1 hour, filter the extract while it is hot, let it cool, and put it on D101 macroporous adsorption resin Column, fully eluted with water until the effluent is clear and has no reducing sugar reaction, then eluted with 70% ethanol, collected the 70% ethanol eluate, recovered to near dryness under reduced pressure, and dried under reduced pressure to obtain paeoniflorin Composition 1.9 kg.

[0069] It was determined that the total glycosides content in the paeoniflorin polyglycoside composition obtained in the above experiment was 63%, of which total glucosides of paeony accounted for 86%, and total saponins of Astragalus accounted for 14%.

Embodiment 2

[0071] Take 80kg of Radix Paeoniae Alba and 20kg of Radix Astragali, cut into decoction pieces, put them in an extraction tank, add 1000L of 70% ethanol to extract 3 times, each time for 1.5h, filter the extract while it is hot, let it cool, and absorb it on NKA macropores Resin column, fully eluted with water until the effluent is clear and has no reducing sugar reaction, then eluted with 70% ethanol, collected 70% ethanol eluate, recovered to near dryness under reduced pressure, and dried under reduced pressure to obtain Paeoniae alba Glycoside composition 1.6kg.

[0072] It was determined that the content of total glycosides in the paeoniflorin polyglycoside composition obtained in the above experiment was 76%, of which total glucosides of paeony accounted for 87%, and total saponins of Astragalus accounted for 13%.

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Abstract

A Chinese medicine in the form of particle, capsule, tablet, or injection for treating chronic hepatitis, hepatofibrosis and early-phase hepatocirrhosis is prepared from white peony root and astragalus root. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, more specifically a pharmaceutical composition for treating liver diseases and a preparation method thereof. Background technique: [0002] Liver disease has a high incidence rate and is one of the common diseases that seriously endanger people's health. At present, although there are many drugs used to treat liver diseases, most of them belong to the auxiliary status. There is no ideal safe and effective anti-hepatitis drug clinically, especially the lack of drugs for the treatment of chronic hepatitis and liver fibrosis. Invention content: [0003] The present invention aims to avoid the shortcomings of the above-mentioned prior art, and provides a paeoniflorin composition for treating liver diseases with high active ingredient content, stable quality and definite curative effect and a preparation method thereof. [0004] The technical scheme that the present...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K36/481A61P1/16A61P31/14
Inventor 魏伟宋力桂双英
Owner 魏伟
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