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Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents

A technology for migraine and uses, applied in the field of pharmaceutical use of the combination of anticonvulsant derivatives and anti-migraine drugs, can solve problems such as patient non-compliance

Inactive Publication Date: 2007-12-05
ORTHO MCNEIL PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In many cases, it is these side effects that lead to noncompliance and self-discontinuation of the drug

Method used

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  • Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents
  • Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents
  • Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents

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Embodiment Construction

[0047] The term "migraine" as used herein refers to a chronic, paroxysmal, debilitating clinical symptom diagnosed by moderate to severe unilateral throbbing headache lasting 4-72 hours, which includes both without aura and with aura Migraine.

[0048] As used herein, "migraine without aura" refers to the occurrence of at least five episodes meeting the following criteria: (a) headache attacks lasting 4-72 hours and having at least two of the following characteristics: side headache, throbbing headache, moderate or severe headache directly interfering with activities of daily living, and pain that is aggravated when going upstairs or doing similar activities; (b) at least one of the following symptoms during the headache: nausea and / or vomiting, dread light or sound.

[0049] As used herein, "migraine with aura" refers to at least two episodes characterized by at least three of the following four characteristics: (a) one or more fully reversible aura symptoms; (b) gradual ons...

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Abstract

The present invention describes a method for the treatment and / or prevention of migraine and associated symptoms (nausea, vomiting, photophobia, phonophobia, etc.) comprising co-therapy with a therapeutically effective amount of one or more anti-migraine agents and one or more anticonvulsant derivatives.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application 60 / 359,894, filed February 26, 2002, which is hereby incorporated by reference in its entirety. Background of the invention [0003] Migraine is characterized by a chronic, paroxysmal, debilitating clinical presentation and is diagnosed by moderate to severe unilateral throbbing headaches lasting 4 to 72 hours. In addition, this headache is sometimes accompanied by transient sensory disturbances (photophobia and phonophobia) and / or gastrointestinal dysfunction (nausea, vomiting). Migraines can be with or without aura. [0004] Migraine without aura was defined as having at least five episodes meeting the following criteria: (a) headache attacks lasting 4-72 hours and having at least two of the following features: unilateral, throbbing Headache, moderate or severe headache that directly interferes with activities of daily living, and pain that is exacerb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/35A61P25/06A61K45/00A61K31/138A61K31/343A61K31/357A61P43/00
CPCA61K45/06A61K31/35A61P25/06A61P25/08A61P25/26A61P43/00A61K2300/00A61K31/255
Inventor I·R·利文斯通
Owner ORTHO MCNEIL PHARM INC
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