Yinzhi huang capsule, its preparation method and use

A technology of Yinzhihuang and soft capsules, applied in the field of Yinzhihuang soft capsules and its preparation, can solve the problems of affecting drug efficacy and aggravating the liver burden of hepatitis patients, and achieve burden reduction, good patient compliance, and controllable dosage Effect

Inactive Publication Date: 2007-10-31
贵州金宇药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For traditional Chinese medicine ingredients, the diluent commonly used to prepare soft capsules is vegetable oil, and Yinzhihuang is a medicine for hepatitis. If vegetable oil (fatty substances) is used as a diluent, it will increase the burden on the liver of hepatitis patients and affect the efficacy of the medicine. Therefore how to select diluent for use and how to improve the drug effect has become a difficult problem in the preparation of Yinzhihuang Soft Capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: prepare soft capsule

[0021] A. Extract preparation:

[0022] Preparation of capillary extract: take capillary, decoct three times with water, 1.5 hours for the first time, 1 hour for the second and third times, combine the decoction, filter, concentrate the filtrate to contain 2g of crude drug per 1ml, add ethanol to make the content Alcohol content reaches 70%, refrigerate for 24 hours, filter, recover ethanol from the filtrate to contain 5g of crude drug per ml, add ethanol to make the alcohol content reach 85%, refrigerate for 24 hours, filter, recover ethanol from the filtrate to contain 10g of crude drug per ml , add about 5 times the amount of water, refrigerate for 48 hours, filter, the filtrate is concentrated into a thick paste, and vacuum-dried to obtain.

[0023] Preparation of Gardenia Extract: Take Gardenia, crush it into a coarse powder, add water to decoct three times, the first and second times each for 1 hour, and the third time for 0.5...

Embodiment 2

[0034] Embodiment 2: prepare soft capsule (400mg / grain)

[0035] Component Quantity (g / 1000 capsules)

[0036] capillary extract 30.2

[0037] Gardenia Extract 16.1

[0038] Baicalin sodium salt 105.6

[0039] Honeysuckle Extract 20.2

[0040] The PEG600 233 prescription is composed as above, and the others are the same as in Example 1.

Embodiment 3

[0041] Embodiment 3: prepare soft capsule (650mg / grain)

[0042] Component Quantity (g / 1000 capsules)

[0043] capillary extract 40

[0044] Gardenia Extract 21.3

[0045] Baicalin sodium salt 139.8

[0046] Honeysuckle extract 26.7

[0047] Polyethylene glycol 400 421.8

[0048] The prescription is composed as above, and others are the same as in Example 1.

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PUM

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Abstract

The present invention provides a sort of anti-hepatitis-jaundice soft capsule and the making method, this also provides the application of this capsule for treating the icteric hepatitis, oxyhepatitis or chronic hepatitis, persisting hepatitis, ABO hemolytic jaundice of newborn and severe hepatitis. The soft capsule of the invention do not contain corrective and antiseptic, it tastes good and the content of this soft capsule is stable and uniform.

Description

technical field [0001] The invention relates to a soft capsule mainly used for treating icteric hepatitis, acute and chronic hepatitis, persistent hepatitis, neonatal ABO hemolytic jaundice and severe hepatitis and a preparation method thereof, in particular to Yinzhihuang soft capsule and a preparation method thereof. Background technique [0002] Yinzhihuang oral liquid is composed of capillary extract, gardenia extract, baicalin and honeysuckle extract. It is a medicine for clinical treatment of liver and gallbladder diseases. The role of alanine aminotransferase is used for acute, persistent, chronic hepatitis and severe hepatitis caused by damp-heat toxin accumulation, and can also be used for comprehensive treatment of other types of severe hepatitis, with definite curative effect. But it contains a large amount of sucrose and honey, which is not conducive to the use of diabetics; the oral liquid also contains sodium benzoate preservatives, and it tastes bitter, and th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/28A61K36/744A61K36/539A61K36/35A61P1/16A61P31/14
Inventor 滕厚雷智红英李桂生
Owner 贵州金宇药业有限公司
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