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Coated up-conversion nanoparticles

a luminescence nanostructured material and up-conversion technology, applied in the direction of photodynamic therapy, chemistry apparatus and processes, and compositions of luminescent compositions, can solve the problems of inability to reliably synthesize such ucnps, and inability to achieve large-scale production

Inactive Publication Date: 2019-04-04
UNIV OF MASSACHUSETTS MEDICAL SCHOOL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

The novel UCNPs exhibit enhanced biocompatibility, improved synthesis efficiency, and increased upconversion luminescence intensity, allowing for high-contrast in vivo imaging and effective photoactivation with minimal toxicity and photodamage, while being suitable for various biomedical applications.

Problems solved by technology

Most photosensitizers are excited by visible or UV light, which has limited penetration depth due to the light absorption and scattering by biological tissues, resulting in ineffective diagnostic and therapeutic effects to internal or large tumors.
However, UCNPs are hindered by the potential toxicity of the lanthanides.
Moreover, most current protocols for synthesizing such UCNPs are not reliable and are not amenable to large-scale productions due to their inconvenient precursor pretreatments, multi-step phase-transitions, and / or long aging processes.
Yet, the byproduct of a water molecule from their high temperature reaction with the mixture of oleic acid and oleyl amine solvents lead to intense explosive boiling, and limiting the reproducibility of the synthesis and uniformity of the nanoparticle products.
In addition, such a complicated two-step approach also hinders the further development of UCNPs in a high throughput manner.

Method used

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Examples

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Materials

[0111]Y2O3, (99.9%), Yb2O3 (99.9%), Tm2O3(99.9%), CF3COONa (99.9%), CF3COOH, CaCO3, 1-octadecene (90%), oleic acid (90%), diethylene glycol (99%), toluene, citric acid monohydrate, 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl ), N-hydroxysulfosuccinimide sodium salt (sulfo-NHS), and branched polyethylenimine (PEI, Mw 25,000) were all purchased from Sigma-Aldrich and used without further purification. The trifluoroacetates of Y, Yb, and Tm were prepared as described. 5-carboxyfluorescein-bis-(5-carboxymethoxy-2-nitrobenzyl) ether, β-alanine-carboxamide, succinimidyl ester (CMNB-caged carboxyfluorescein, SE) were purchased from Invitrogen.

Preparation of Ln trifluoroacetates

[0112]Ln2O3 powder was mixed with a little of water to form a slurry in a single-neck flask, then trifluoroacetic acid with 150% stoichiometric ratio was added under stirring. When the exothermic process was finished, the single-neck flask was heated to reflux under water condenser....

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Abstract

The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising α-Na Lna, Lnb Lnc F4) and an epitaxial shell (e.g., formed from CaF2; wherein Lnb is Yb), and related methods of preparation and uses thereof.

Description

PRIORITY CLAIMS AND RELATED PATENT APPLICATIONS[0001]This application claims priority to U.S. Provisional Patent Application Ser. Nos. 61 / 653,406, filed May 30, 2012, and 61 / 765,019, filed Jul. 24, 2012, the entire content of each of which is incorporated herein by reference in its entirety for all purposes.TECHNICAL FIELD OF THE INVENTION[0002]The present invention generally relates to upconversion luminescence nano-structured material(s) and methods for preparation and uses thereof. More particularly, the invention relates to a novel biocompatible upconversion nanoparticle (UCNP) comprising a core of cubic nanocrystals (e.g., comprising α-Na Lna, Lnb Lnc F4) and an epitaxial shell (e.g., formed from CaF2; wherein Lnb is Yb).BACKGROUND OF THE INVENTION[0003]Upconversion nanoparticles (UCNPs) have recently emerged as a new class of materials with potential applications in a wide-range of fields, such as biosensing, chemical sensing, in vivo imaging, drug delivery, photodynamic thera...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K49/00C09K11/02C01F17/00A61K41/00C09K11/77B82Y5/00
CPCC09K11/7773B82Y5/00A61K49/0067A61K49/0019A61K49/0052C01P2004/64C01P2004/04C01P2004/02C01P2002/84C01P2002/72C01F17/0031A61K49/0093A61K49/0065A61K41/008C09K11/025C01F17/36
Inventor HAN, GANGSHEN, JIE
Owner UNIV OF MASSACHUSETTS MEDICAL SCHOOL
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