Therapeutic agents containing cannabis flavonoid derivatives targeting kinases, sirtuins and oncogenic agents for the treatment of cancers

Abstract

A cannabis-based flavonoid pharmaceutical composition including any one or more selected from among the group of Cannflavin A, Cannflavin B. Cannflavin C, Chrysoeriol, Cosmosiin, Flavocannabiside and their derivatives selected from among the group of Geraldol, Rhamnetin, Isorhamnetin, Rhamnazin, or their synthases, for the prevention and treatment of certain cancers that can be treated by therapeutically targeting oncogenic factors including kinases, sirtuins, bromodomains, matrix metalloproteinases and histone acetylases. Some of the cancers that can be treated by use of cannabis flavonoids based on the inhibition of these therapeutic targets include but are not limited to brain, breast, colon, renal liver, lung, pancreatic, pigmented villonodular synovitis, prostate, leukemia, melanomam, tenosynovial giant cell tumor, as well as any other cancers that overexpress the oncogenic factors inhibited, by the cannabis flavonoids or their derivatives herein identified.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation-in-part of U.S. patent application Ser. No. 14 / 835,198 filed 25 Aug. 2015, and is a continuation-in-part of PCT Patent Application PCT / US15 / 62331 filed 24, Nov. 2015.BACKGROUND OF THE INVENTION1. Field of the Invention[0002]The present invention relates to flavonoid derivatives and, more particularly, to cannabis flavonoid derivatives or the pharmaceutically acceptable salt thereof that may be used in a pharmaceutical composition for preventing and treating cancer.2. Description of the Background[0003]Flavonoids are common constituents of plants and cover a wide range of functions including acting as yellow pigments in petals and leaves to attract pollinating insects. They might also appear as bluish pigments (anthocyanins) to receive certain wavelengths of light, which permits the plant to be aware of the photoperiod. Many of these flavonoids also protect the plants by being involved in the filte...

AI Technical Summary

Benefits of technology

The present invention provides a method for using specific cannabis-based flavonoid pharmaceutical compositions for the prevention and treatment of cancer. These flavonoids have been isolated and successfully synthesized, and their anticancer efficacy has been demonstrated in various assays. The invention also provides a method for isolating and synthesizing these flavonoids from raw plant material. The flavonoid-based pharmaceutical compositions have a specific structure and may be used alone or in combination with other bioactive compounds to treat or prevent cancer.

Problems solved by technology

Unfortunately much attention on Cannabis is focused on its recreational use as a psychoactive drug.

Despite the foregoing, there has been little prior effort to detail the use of flavonoid derivatives for a “molecular treatment approach”, e.g., the targeting of kinases, sirtuins, matrix metalloproteinase, bromodomains and histone deacetylases by the cannflavins, cannabis flavonoids or their analogs in the treatment of cancer utilizing FDA approved therapeutic targets.

However, different cancers respond differently to various oncogenic agents and that is why the response of an outgrowth line to a combination of several agents is unpredicatble.

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