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Compositions and methods for providing hematopoietic function without HLA matching

a technology of hematopoietic function and composition, applied in the field of compositions and methods for providing hematopoietic function to human, can solve the problems of organ transplant rejection, increase morbidity and mortality, and significant infection risk, and achieve the effects of increasing the number of scid repopulation cells, increasing the number of hematopoietic stem cells, and increasing the number of cd34+ cells

Inactive Publication Date: 2018-03-29
FRED HUTCHINSON CANCER RES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach enables rapid hematopoietic recovery and hematopoietic function in patients with pancytopenia or neutropenia, facilitating autologous recovery and reducing the risk of graft-versus-host disease, while allowing for the creation of an 'off-the-shelf' stem cell product that can be stockpiled for widespread use.

Problems solved by technology

Of particular concern is prolonged neutropenia, which results in a significant risk of infection despite improved antimicrobial therapy and increases morbidity and mortality.
They may be the cause of organ transplant rejections.
Once the stem cell differentiates into a myeloid progenitor cell, its progeny cannot give rise to cells of the lymphoid lineage, and, similarly, lymphoid progenitor cells cannot give rise to cells of the myeloid lineage.

Method used

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  • Compositions and methods for providing hematopoietic function without HLA matching
  • Compositions and methods for providing hematopoietic function without HLA matching
  • Compositions and methods for providing hematopoietic function without HLA matching

Examples

Experimental program
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Embodiment Construction

[0060]The present invention provides a method for providing hematopoietic function to a human patient in need thereof by administering an expanded human cord blood stem cell sample to the patient, wherein said administering is done without matching the HLA-type of the expanded human cord blood stem cell sample to the HLA type of the patient. By “without matching the HLA-type,” what is meant is that no steps are taken to have any of the HLA antigens or alleles match between the patient and the sample. In one embodiment, the expanded human cord blood stem cells can differentiate into cells of the myeloid lineage. In another embodiment, the expanded human cord blood stem cell can differentiate into cells of the lymphoid lineage. The selection of the Expanded CB Stem Cells to be administered to the patient is done without taking into account whether the patient to whom the Expanded CB Stem Cells will be administered matches or mismatches the Expanded CB Stem Cells at any of the HLA anti...

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Abstract

The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem / progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem / progenitor sample or the HLA-type of the patient; and administering the selected expanded human cord blood stem / progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem / progenitor cell samples, banks of frozen expanded human cord blood stem / progenitor cell samples, and methods for producing such banks are also provided herein.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 13 / 640,297 filed Dec. 21, 2012, which is a national phase of International Application No. PCT / US2011 / 031953, filed Apr. 11, 2011, which claims benefit of U.S. Provisional Application No. 61 / 322,544, filed Apr. 9, 2010, each of which are incorporated by reference herein in their entirety.STATEMENT OF GOVERNMENT SUPPORT[0002]This invention was made with government support under HHS010020080064C awarded by the Department of Health and Human Services and HL101844 awarded by the National Institutes of Health. The government has certain rights in the invention.FIELD OF THE INVENTION[0003]The present invention relates to methods and compositions for providing hematopoietic function to human patients in need thereof, by selecting an expanded human umbilical cord blood stem / progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem cell / prog...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/51G06F19/00C12N5/0789A61K35/50
CPCC12N2501/42C12N2501/26C12N2501/2303C12N2501/145G06F19/34C12N5/0647A61K35/51A61K35/50C12N2501/125A61K35/28G16H20/40G16H10/40A61P35/02A61P7/00A61P7/06Y02A90/10
Inventor BERNSTEIN, IRWIN D.DELANEY, COLLEEN
Owner FRED HUTCHINSON CANCER RES CENT
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