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Composition for enhancing memory and learning function and/or cognitive function

a cognitive function and memory enhancement technology, applied in the field of peptides, can solve the problems of increasing the mental disorder caused by the decline of brain function, the active ingredient(s) are social issues, and the mechanism of action remains unknown, so as to improve brain function, enhance memory and learning function and/or cognitive function, enhance memory and learning function and/or cognitive function

Active Publication Date: 2017-07-27
KIRIN HOLDINGS KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides peptides that improve brain function, especially memory and learning, and can be used to create compositions, foods, and medications that enhance these functions. The peptides can help improve the cognitive function of young people and prevent decline in older individuals. The compositions, foods, and medications are also useful in maintaining and improving the cognitive function by enhancing the activity of microglia to remove waste materials and prevent inflammation in the brain. The active ingredients in the invention are peptides found in daily foods, so they have minimal side effects.

Problems solved by technology

Furthermore, the increase of the mental disorder caused by the decline of the brain function associated with the aging in the aged has become a social issue as a result of increase of the aged.
However, these research results are those of epidemiological investigations and the actual active ingredient(s) and the mechanism of action remain unknown.
While the waste material removal in the brain and the promotion of generation of synapses by microglia contribute to the maintenance, improvement and amelioration of the cognitive function, it has been reported that the excessive activation of microglia may induce an inflammatory state and cause the decline of the cognitive function (Non-Patent Literature 6 to 9).

Method used

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  • Composition for enhancing memory and learning function and/or cognitive function
  • Composition for enhancing memory and learning function and/or cognitive function
  • Composition for enhancing memory and learning function and/or cognitive function

Examples

Experimental program
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Effect test

examples

[0084]The present invention will be described in detail by way of the following examples, but the present invention is not limited by them.

[Preparation of Whey Peptide Extract]

[0085]Whey peptide extracts were prepared as follows. 0.125% (w / v) of a food additive protease or peptidase was mixed with a 5% (w / v) whey (Daiichi Kasei Co., Ltd.) aqueous solution and the mixture was reacted at 50 degrees Celsius for 4 hours. The obtained enzymatic reaction solution is filtered with a ultrafilter having a molecular weight cut-off of 10 KDa and the filtrate (hereinafter, also referred to as whey peptide extract) was collected and used for experiments.

[Method of Evaluating Memory and Learning Function and Cognitive Function]

[0086]FIG. 1A illustrates a summary of methods of evaluating the memory and learning function and the cognitive function. To 6-week-old male CD-1 mice, 1 mg / kg of the peptide extract or 0.1-3 μmol / kg of a synthetic peptide is orally administered forcibly into stomach and 40...

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Abstract

Compositions, foods, and medicaments for enhancing memory and learning function and / or cognitive function are provided. Compositions, foods, and medicaments for improving brain function and particularly enhancing memory and learning function and / or cognitive function can be provided by including a peptide including an amino acid sequence set forth in any one of SEQ ID NOs 1 to 16 as an active ingredient.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a National Stage of International Application No. PCT / JP2015 / 067344 filed Jun. 16, 2015, claiming priority based on Japanese Patent Application No. 2014-123073 filed Jun. 16, 2014 and Japanese Patent Application No. 2014-228391 filed Nov. 10, 2014, the contents of all of which are incorporated herein by reference in their entirety.TECHNICAL FIELD[0002]The present invention relates to peptides having activity to enhance memory and learning function and / or cognitive function, and to compositions, foods, and medicaments containing such a peptide.BACKGROUND ART[0003]The maintenance, improvement, and amelioration of the brain function are desired by wide generations of people from the youth to the aged. The maintenance, improvement, and amelioration of the memory and the learning ability are important not only for students and working adults studying for entrance and qualifying examinations, but also for conducting daily wo...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/01A23L33/10A23L33/19A23L33/175A23L33/00A23L33/18A61K38/08
CPCA61K38/018A23L33/40A23L33/18A23V2002/00A23L33/175A23L33/10A23L33/19A61K38/04A23J3/343A61K38/05A61K38/06A61K38/07A61K38/08A61K38/10A61P25/28A61P29/00A61P43/00A23V2200/322A23V2250/55
Inventor ANO, YASUHISAKUTSUKAKE, TOSHIKO
Owner KIRIN HOLDINGS KK
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