Method of thermal treatment for myolysis and destruction of benign uterine tumors

a technology of myolysis and uterine tumors, applied in the field of ultrasound therapy of uterine fibroids, can solve the problem of thermally fixing volume, and achieve the effect of reducing treatment time and improving the chance of complete regression

Inactive Publication Date: 2015-01-15
ACOUSTIC MEDSYST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a system and methods for using ultrasound technology to treat fibroids by heating or ablating them. This allows for directional control and deep penetration of energy patterns for directed thermal arterial occlusion / coagulation. The system is minimally-invasive and can be used to treat large fibroids by targeting a smaller portion of the tumor with the feeding vasculature, reducing treatment time and improving chances for complete regression. It also allows for more efficient use of energy, reducing the volume of tissue that needs to be thermally fixed or destroyed, which may remain in the body for some time. Overall, this invention provides a better alternative treatment for women who want to bear children and offers improved outcomes with reduced risk and recovery time.

Problems solved by technology

In addition, this requires less of a volume be thermally fixed or destroyed, which may remain in the body for some time and in some circles considered clinically undesirable.

Method used

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  • Method of thermal treatment for myolysis and destruction of benign uterine tumors
  • Method of thermal treatment for myolysis and destruction of benign uterine tumors
  • Method of thermal treatment for myolysis and destruction of benign uterine tumors

Examples

Experimental program
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experiment # 1

Experiment #1

[0108]Ultrasound interstitial applicators were evaluated for interstitial hyperthermia for combination with radiation or drug therapy, as well as localized thermal ablation. The interstitial ultrasound applicators utilized arrays of small tubular ultrasound radiators, designed to be inserted within plastic implant catheters typically used for interstitial HDR brachytherapy. Water-flow was used during power application to couple the ultrasound and improve thermal penetration. Multi-transducer devices were evaluated with transducer diameters between 1.2 mm-3.5 mm and outer catheter diameters between 2.1 mm (14 gauge) and 4.0 mm (12 Fr), respectively, with 1.5 mm OD transducers and 13 g (2.4 mm OD) catheters the most common configuration. The applicators were fabricated with multiple tubular segments, with separate power control, so that the power deposition or heating pattern could be adjusted in real time along the applicator axis.

[0109]The ultrasound energy emanating fr...

experiment # 2

Experiment #2

[0121]A family of interstitial ultrasound applicators was fabricated using 2-4 cylindrical piezo-ceramic crystal transducers (PZT-4) with outer diameters (OD) of 1.5 or 2.5 mm and lengths of 10-15 mm. The configurations tested were 1.5 mm OD×10 mm long transducers in linear arrays of two, three and four adjacent transducers, an array of three 2.5 mm OD×15 mm long adjacent transducers, and an array of one 2.5 mm OD×15 mm long transducer adjacent to two 2.5 mm OD×10 mm transducers.

[0122]The operating frequencies of the transducers ranged from 6.5 to 8 MHz. For some of the applicators, the transducers were sectored to produce a 180° actively acoustic sector for directional power deposition. The transducers were mounted on support structures, and a bio-inert plastic layer was applied for electrical and biological insulation. The 1.5 mm OD applicators were inserted into 13 gage brachytherapy catheters (2.4 mm OD), and the 2.5 mm OD applicators into custom PET catheters (3.7 ...

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Abstract

A high-power ultrasound heating applicator for minimally-invasive thermal treatment of uterine fibroids or myomas. High-Intensity interstitial ultrasound, applied with minimally-invasive laparoscopic or hysteroscopic procedures, is used to effectively treat fibroids within the myometrium in lieu of major surgery. The applicators are configured with high-power capabilities and thermal penetration to treat large volumes of fibroid tissue (>70 cm3) in short treatment times (3-20 minutes), while maintaining three-dimensional control of energy delivery to thermally destroy the target volume.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 11 / 738,391 filed on Apr. 20, 2007, now U.S. Pat. No. ______, incorporated herein by reference in its entirety, which claims the benefit of U.S. provisional patent application Ser. No. 60 / 885,845 filed on Jan. 19, 2007, incorporated herein by reference in its entirety, U.S. provisional patent application Ser. No. 60 / 797,421 filed on May 3, 2006, incorporated herein by reference in its entirety, and U.S. provisional patent application Ser. No. 60 / 793,750 filed on Apr. 20, 2006, incorporated herein by reference in its entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]Not ApplicableINCORPORATION-BY-REFERENCE OF COMPUTER PROGRAM APPENDIX[0003]Not ApplicableNOTICE OF MATERIAL SUBJECT TO COPYRIGHT PROTECTION[0004]A portion of the material in this patent document is subject to copyright protection under the copyright laws of the United States and of...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N7/02
CPCA61N2007/0078A61N2007/0004A61N7/022A61B2017/4216A61B17/2202A61N5/045A61N7/02A61N2005/1094
Inventor DIEDERICH, CHRIS J.NAU, WILL H.JACOBY, ALISON F.DEARDORFF, DANA L.BURDETTE, EVERETTE C.
Owner ACOUSTIC MEDSYST
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