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Kit and devices for organ perfusion

a technology for organs and kits, applied in the field of medical treatment systems, can solve the problems of inadvertently reaching other non-targeted organs, affecting the treatment effect, so as to reduce the operative trauma, avoid hospitalization, and shorten the operation procedure

Inactive Publication Date: 2015-01-15
MEDICAL DEVICE WORKS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a kit for delivering a therapeutic agent to an organ blood flow and removing excess therapeutic agent without causing blockages in the main systemic arteries and veins. The kit includes a therapeutic agent, a first retrievable medical device for delivering the therapeutic agent to the organ blood flow, a second retrievable medical device for isolating the organ outflow, and a separation device for filtering the collected blood from the therapeutic agent excess. The invention allows for high dose drug therapy in a localized environment and reduces operative trauma and hospital stay.

Problems solved by technology

A common issue with RE is extrahepatic embolization to the gastric artery or the lungs.
Non-targeted delivery of the embolic agent may have significant unwanted effects on the human body.
For example, in liver treatment, a number of microspheres can inadvertently reach other non-targeted organs in the body.
This has undesirable impacts on other organs including the stomach, the gall bladder, the pancreas and the small intestine and can cause inflammation of the gall bladder (cholecystitis), stomach (gastritis) or intestine (duodenitis).
In uterine fibroid treatment, the non-targeted delivery of the embolic agent may embolize one or both ovaries leading to loss of menstrual cycle, subtle ovarian damage that may reduce fertility, early onset of menopause and in some cases substantial damage to the ovaries.
Other unintended adverse events including pain and necrosis might appear.
These complications require additional medical treatment and might be lethal for the patient which is an enormous disadvantage of RE.
For colorectal cancer liver metastasis, at least 20% of the patients may not benefit from RE due to the presence of an intolerable shunt to the lung and up to 38% of the patients may require a reduced dose (which may require an additional, costly treatment).
The use of occlusion devices in this system is disadvantageous as the systemic blood flow is interrupted during the treatment, which may not be well tolerated by the patient and can cause hypovolemia.
Another drawback of the system of WO 2011 / 05618 is the use of balloon type devices to occlude the vena cava.
These types of devices are highly prone to leakages and migration / rotation.

Method used

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  • Kit and devices for organ perfusion
  • Kit and devices for organ perfusion
  • Kit and devices for organ perfusion

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Embodiment Construction

[0052]Unless otherwise defined, all terms used in disclosing the invention, including technical and scientific terms, have the meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. By means of further guidance, term definitions are included to better appreciate the teaching of the present invention.

[0053]As used herein, the following terms have the following meanings:

[0054]“A”, “an”, and “the” as used herein refers to both singular and plural referents unless the context clearly dictates otherwise. By way of example, “a compartment” refers to one or more than one compartment.

[0055]“About” as used herein referring to a measurable value such as a parameter, an amount, a temporal duration, and the like, is meant to encompass variations of + / −20% or less, preferably + / −10% or less, more preferably + / −5% or less, even more preferably + / −1% or less, and still more preferably + / −0.1% or less of and from the specified value, in so far such varia...

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Abstract

The present invention provides a kit for the delivery a therapeutic agent to an organ blood flow and the removal of the excess of said therapeutic agent from said organ blood flow, said kit comprises: (a) the therapeutic agent, (b) a first retrievable medical device (26), for delivering said therapeutic agent into the organ inflow, (c) a second retrievable medical device for isolating the organ outflow vessel and (d) a separation device (25) comprising at least one filter able to separate the therapeutic agent excess from the organ outflow, having an inlet (38) for the organ outflow having a therapeutic agent excess and an outlet (39) for filtered organ outflow.

Description

FIELD OF THE INVENTION[0001]The present invention generally relates to the field of medical treatment systems. More particularly, the present invention relates to system, devices, kits and methods to deliver a therapeutic agent and remove its excess during an interventional procedure.BACKGROUND[0002]Embolization, chemo-embolization and radio-embolization therapy are often clinically used to treat a range of diseases, such as hypervascular liver tumors, uterine fibroids, secondary cancer metastasis in the liver, pre-operative treatment of hypervascular menangiomas in the brain and bronchial artery embolization for hemoptysis. An embolizing agent may be embodied in different forms, such as beads, liquid, foam, or glue placed into an arterial vasculature or any combination thereof. The beads may be uncoated or coated. Where the beads are coated, the coating may be a chemotherapy agent, a radiation agent or other therapeutic agent. When it is desirable to embolize a small blood vessel, ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M1/34A61M25/10A61M5/142A61N5/10A61M1/36
CPCA61M5/142A61M1/3615A61M25/10A61M1/3455A61M2025/1052A61N5/1002A61B17/12036A61B17/1204A61B17/12109A61B17/12172A61M1/3621A61M25/0074A61B2017/00893A61B2017/12054A61B2017/1205A61M25/0075A61M25/007A61M25/1018A61M25/10183A61M1/3613A61M2025/105A61B17/12136A61M1/32A61M1/34A61M1/367A61M2205/3303A61M2205/3344
Inventor FIERENS, JOOPNACKARD, KEVIN JASONMARCOUX, ERIC THIERRY JEANBARTHOLOME, EMMANUEL J.
Owner MEDICAL DEVICE WORKS NV
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