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Integrated multipelx target analysis

a target analysis and multi-pelx technology, applied in the field of integrated multi-pelx target analysis, can solve the problem of virtually no such commercial system

Inactive Publication Date: 2014-10-30
ROCHE MOLECULAR SYST INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a cartridge for conducting assays. The cartridge has a liquid regent module (LRM) with blisters containing assay reagents, which can be dispensed at a remote location upon rupture of the blister. The cartridge also includes an actuator component and a motion conversion mechanism that causes movement of the platen in the second direction. The technical effects of the invention include efficient and reliable dispensing of assay reagents and sample components, as well as improved accuracy and reliability of the resulting assay results.

Problems solved by technology

One major challenge in the area of clinical and molecular diagnostics is the ability to have a “sample to answer” system that allows minimal sample handling and preparation, rapid assays as well as no requirement for highly trained laboratory personnel.
While many systems have been proposed, to date there are virtually no such commercial systems.

Method used

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Examples

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Embodiment Construction

I. Introduction

[0109]One major challenge in the area of clinical and molecular diagnostics is the ability to have a “sample to answer” system that allows minimal sample handling and preparation as well as no requirement for trained clinical lab personnel. While many systems have been proposed, to date there are virtually no such commercial systems. The present invention provides such an integrated, multiplex system. One of the significant benefits of the present system is that in many embodiments, the chip itself needs no moving parts, such as valves or pumps, due to the unique transport properties of the electrowetting system described below.

[0110]The present invention provides molecular diagnostic methods and compositions based on the detection of target analytes, including nucleic acids. The systems described herein are complete integrated “sample to answer” systems, in contrast with current commercial systems that require some off chip handling of the sample, generally including...

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Abstract

This invention provides biochip cartridges and instrument devices for the detection and / or analysis of target analytes from patient samples.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of provisional patent application Ser. No. 61 / 717,887, filed Oct. 24, 2012, and Ser. No. 61 / 798,091, filed Mar. 15, 2013, both of which are hereby incorporated by reference in their entirety, and particularly for the Figures and Legends contained therein.BACKGROUND OF THE INVENTION[0002]One major challenge in the area of clinical and molecular diagnostics is the ability to have a “sample to answer” system that allows minimal sample handling and preparation, rapid assays as well as no requirement for highly trained laboratory personnel. While many systems have been proposed, to date there are virtually no such commercial systems. The present invention provides such an integrated, multiplex system.BRIEF SUMMARY OF THE INVENTION[0003]The present invention provides biochip cartridges and instrument devices for the detection and / or analysis of target analytes from patient samples.[0004]Accordingly, in one as...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/68
CPCC12Q1/6825B01L3/502715B01L3/50273B01L3/502761B01L2200/0621B01L2200/0631B01L2200/10B01L2200/16B01L2300/044B01L2300/0672B01L2300/0816B01L2300/123B01L2400/0427B01L2400/0481B01L7/525B01L2400/0683G01N35/00722G01N2035/00019G01N2035/00366G01N2035/00752G01N2035/0091G01N35/00732
Inventor KAYYEM, JON FAIZSRINIVASAN, JAY
Owner ROCHE MOLECULAR SYST INC
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