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Composition with Sustained Antimicrobial Activity

Inactive Publication Date: 2014-08-28
THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text is discussing the use of emollients like farnesol or dipropylene glycol to enhance the penetration of antimicrobial agents into the skin. This helps to prolong the effectiveness of the antimicrobial agents.

Problems solved by technology

Studies have shown that the rate of compliance by the healthcare workers with the hand washing guidelines is lower than 50% partly because of the possibility / fear of skin irritation with the frequent use of soaps and partly due to lack of time.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

5. EXAMPLE 1

Comparison of Persistent Activities of Commercial Soaps With LPS 14E- and LPS 14 7-2 (the Compositions of Which are Described Above)

[0073]Method of Testing Substantive Activity:

[0074]Pigskins (3 cm2 mounted on petri dishes) were washed with non antibacterial soap and rinsed under running tap water. 3 pairs for control (Soap base) and 3 pairs for test were used. 0.15 ml soap was added to each piece of the pair and rubbed for 30 seconds and rinsed each piece with 75 ml water. After 1 or 2 hours, the pieces were contaminated with 10 μl of 105 Cfu / ml bacterial culture. After 15 minutes the pieces were rinsed with 10 ml of drug inactivating fluid (DNF). The fluid was diluted and plated on TSA. After incubation at 37° C., the bacterial counts were enumerated and the 3 soaps were compared[0075]1=“DC” (0.46% T) Commercial soap containing 0.46% triclosan[0076]2=“TPB”, Comercial soap containing 0.15% triclosan, PHMB and Benzathonium chloride without emollients[0077]3=LPS 14E Soap ...

example 2

6. EXAMPLE 2

Comparison of Persistent Activities of Commercial Hand Sanitizers With HSBZT and HSBAC (The Compositions of which are Described Above)

[0083]A method analogous to that used to test the soaps (above) was used to test persistent antimicrobial activities of hand sanitizers. The test organism was S. aureus and HSP is a commercial alcohol-based hand sanitizer. The results are shown in Table 2.

TABLE 2Log10 reduction fromcontrol countsDisinfectant1 hour post application4 hour Post applicationHSBZT2.8512.130HSBAC3.22.9HSP0.1020.050

Conclusion Both aqueous HSBZT and HSBAC show grater activity than the commercial alcohol-based hand sanitizer tested.

example 3

7. EXAMPLE 3

Evaluation of Anti Irritant Composition (ZAB) in an Alcohol Based Hand Disinfectant

[0084]Alcohol based hand disinfectant (ABHD)

Ingredients% w / wAlcohol SDA 40 B70.0Benzyl alcohol1.0Lactic acid0.2Octanediol1.0Dipropylene glycol1.0Farnesol0.5Benzathonium chloride0.18PHMB0.3Polyquaternium-100.1Hydroxypropyl methyl cellulose0.1Incromine oxide1.0Water23.62Total99.0

[0085]ABHD with the following ingredients were prepared for testing in volunteers for anti irritant effect. These ingredients were added to the above ABHD and total weight adjusted to 100 gm with water

ABHD ZABHD containing 0.2% zincgluconateABHDZ1ABHD containing 0.2% zincgluconate + 0.2% ZinclactateABHD ZAABHD containing 0.2% zinc gluconate + 0.5%Aloe leaf juiceABHD ZBABHD containing 0.2% zinc gluconate + 0.2% bisabololABHD ZABABHD containing 0.2% zinc gluconate + 0.5% Aloe leafJuice + 0.2% bisabololABHD ZAB 1ABHD containing 0.2% zincgluconate + 0.25%Aloe leaf Juice + 0.1% bisabolol

[0086]Volunteer Test Results:

[0087]...

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Abstract

Disclosed herein are compositions comprising benzyl alcohol, one or more cationic antimicrobial agent, and one or more emollient, the combination of which results in persistent antimicrobial activity after application to the skin. The compositions optionally further comprise an organic acid and / or a zinc salt, such as zinc gluconate, as an anti-irritant.

Description

PRIORITY CLAIM[0001]The present application is a continuation of International Application No. PCT / US12 / 063,013, filed Nov. 1, 2012, which claims priority to U.S. Provisional Patent Application Ser. No. 61 / 555,367, filed Nov. 3, 2011, U.S. Provisional Patent Application Ser. No. 61 / 583,505, filed Jan. 5, 2012, and U.S. Provisional Patent Application Ser. No. 61 / 668,160, filed Jul. 5, 2012, to each of which priority is claimed and all of which are incorporated herein by reference in their entireties.1. INTRODUCTION[0002]Disclosed herein are compositions comprising benzyl alcohol, a cationic antimicrobial agent, and an emollient, the combination of which results in persistent antimicrobial activity when applied to the skin.2. BACKGROUND[0003]Hand hygiene guidelines for healthcare personnel published by the Centers for Disease Control and Prevention recommend that alcohol-based hand gels and foams be used routinely, with intermittent thorough hand washing with soaps throughout the day....

Claims

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Application Information

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IPC IPC(8): A01N47/40
CPCA01N47/40A61K31/045A61K31/14A61K8/34A61K8/39A61K8/416A61K8/43A61Q17/005A61K2300/00
Inventor MODAK, SHANTA M.DONGRE, SANTOSHKUMAR
Owner THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
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