Methods to facilitate transmission of large molecules across the blood-brain, blood-eye, and blood-nerve barriers

a technology of large molecules and transmission channels, which is applied in the direction of antibody medical ingredients, extracellular fluid disorders, therapy, etc., can solve the problems of not disclosing the use of these substances, the use of vvs, so as to reduce the rate of progress, improve the effect of adverse conditions, and stop the progression of an illness

Inactive Publication Date: 2013-01-24
TACT IP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to a method of delivering a large molecule, such as golimumab, to the brain, eye, retina, auditory apparatus, spine, and other areas using perispinal administration. This method involves placing the medication directly in the spinal column, which allows for enhanced delivery and reduced dosage requirements. The invention also utilizes the vertebral venous system for delivering the medication to the brain through retrograde flow. The technical effects of this method include improved efficacy and reduced side effects.

Problems solved by technology

This patient application does not disclose the use of these substances to treat disorders of the brain.
But neither Clemens nor Vogelsang discussed the use of the VVS to facilitate delivery of large molecules to the brain, nor did they discuss the use of the VVS for therapeutic purposes.
But Groen did not discuss the use of the VVS to facilitate delivery of large molecules to the brain, nor did he discuss the use of the VVS for therapeutic purposes.

Method used

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  • Methods to facilitate transmission of large molecules across the blood-brain, blood-eye, and blood-nerve barriers
  • Methods to facilitate transmission of large molecules across the blood-brain, blood-eye, and blood-nerve barriers
  • Methods to facilitate transmission of large molecules across the blood-brain, blood-eye, and blood-nerve barriers

Examples

Experimental program
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Embodiment Construction

[0153]The use of perispinal administration of cytokine antagonists to treat neurological disorders is discussed in US patent application 20030049256 of this inventor. The use of perispinal administration without direct intrathecal injection and the vertebral venous system to deliver large molecules to the brain, the eye, and the auditory apparatus are discussed in the following provisional patent applications:[0154]60 / 585,735 filed Jul. 6, 2004;[0155]60 / 659,414 filed Mar. 9, 2005;[0156]60 / 662,744 filed Mar. 17, 2005;[0157]and 60 / 669,022, filed Apr. 7, 2005,

[0158]This is a continuation-in-part of U.S. patent application Ser. No. 11 / 016,047, filed Dec. 18, 2004, entitled “Methods of use of etanercept to improve human cognitive function”, which is a continuation-in-part of U.S. Patent Application 20030049256, also known as U.S. patent application Ser. No. 10 / 269,745, entitled “Cytokine antagonists for neurological and neuropsychiatric disorders”, filed Oct. 9, 2002, now U.S. Pat. No. 6...

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Abstract

A method for delivering a biologic to a human, comprising administering said biologic parenterally into the perispina! space of said human without direct intrathecal injection and positioning said human in a Trendelenburg position.

Description

1. CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of application Ser. No. 12 / 568,661, filed Oct. 19, 2009, which is a continuation of application Ser. No. 11 / 601,799, filed Nov. 17, 2006, now U.S. Pat. No. 7,629,311, which is a continuation-in-part of application Ser. No. 11 / 016,047, filed Dec. 18, 2004 now U.S. Pat. No. 7,214,658. All of the above patents and patent applications included in this paragraph are incorporated by reference in their entirety herein.[0002]This application is also related to provisional U.S. patent application 60 / 662,744 entitled “Methods of Use of the Vertebral Venous System to Deliver Biologics to the CNS” filed Mar. 16, 2005. In addition to the above, this application claims priority from U.S. provisional application 60 / 585,735, filed Jul. 6, 2004; U.S. provisional application 60 / 738,331, entitled “Methods to facilitate transmission of golimumab and other therapeutic molecules across the blood-brain barrier”, filed Nov. ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/395A61K38/27A61K38/49A61P29/00A61K38/18A61K51/10A61P25/28A61P25/00A61K38/17A61K38/48
CPCA61K38/1816A61K38/215C07K16/241A61K38/49A61K2039/54A61K38/27A61P25/00A61P25/28A61P29/00
Inventor TOBINICK, EDWARD LEWIS
Owner TACT IP
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