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Polypeptides useful for appetite suppression

a technology of polypeptides and appetite suppression, which is applied in the field of polypeptides, can solve the problems of releasing nitrogen, and reducing the effect of phospholipids

Inactive Publication Date: 2010-11-18
NELSON RALPH A +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Loss of bone mass in space is one of the major problems that prevents long term space flights by humans.
This process not only depletes body muscle, it also releases the toxic form of nitrogen as ammonia.
Under similar stimuli, humans would suffer severe bone loss.
In the human, a supine state inhibits normal bone remodeling and leads to severe loss of calcium and bone.

Method used

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  • Polypeptides useful for appetite suppression
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Examples

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Embodiment Construction

[0096]Methods used in this study relate to two newly discovered approaches. One is careful monitoring of annual weight and food intake changes in black bears as a measure for anorexia and hyperphagia. The other is use of cutting-edge technology which can be exemplified by Surface Enhanced Laser Desorption / Ionization (SELDI) and Matrix Assisted Laser Desorption / Ionization (MALDI) to identify and isolate specific peptides.

Animals

[0097]Thirteen captive adult American black bears (Ursus americanus) used in the study were maintained at the USDA approved Carle Foundation Bear Research Facility in Champaign County, Ill. All were unmated and physically isolated. The experimental protocol to obtain blood samples was approved by the Carle Foundation Hospital Institutional Animal Care and Use Committee. Bears were housed individually in covered indoor / outdoor enclosures and exposed to natural environmental conditions. Bears were maintained on generic dog chow or Sportsman's Choice®. Food was r...

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Abstract

The present invention relates to polypeptides obtained from bear derivative isolate which are useful in suppressing appetite. The polypeptides of the present invention are most preferably between 12 and 13 amino acid residues in length and a mass of about 1249. The present invention also relates to a method of treating obesity by administering to obese subjects an effective amount of the polypeptides of the present invention.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation of pending application U.S. Ser. No. 11 / 198,768, filed Aug. 5, 2005, which is a continuation-in-part of U.S. Ser. No. 10 / 841,710, filed May 7, 2004, now U.S. Pat. No. 7,060,300; which is a continuation application of U.S. Ser. No. 10 / 232,880, filed Aug. 30, 2002 now U.S. Pat. No. 6,855,337; which is a continuation of U.S. Ser. No. 08 / 833,096, filed Apr. 4, 1997 now abandoned; which is a continuation-in-part of U.S. Ser. No. 08 / 470,750, filed Jun. 6, 1995 now abandoned; which is a continuation-in-part of U.S. Ser. No. 08 / 259,788, filed Jun. 14, 1994 now abandoned; which is a continuation-in-part of U.S. Ser. No. 08 / 079,089, filed Jun. 17, 1993 now abandoned, wherein said applications are incorporated herein.FIELD OF THE INVENTION[0002]The present invention relates to polypeptides obtained from bear derivative isolate which are useful in suppressing appetite. The present invention also relates to a ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07K7/00
CPCA61K35/16A61K35/22C07K14/51C07K7/08A61K38/00
Inventor NELSON, RALPH A.SHOEMAKER, JAMES D.
Owner NELSON RALPH A
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