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Three-dimensional porous hybrid scaffold and manufacture thereof

a hybrid scaffold and three-dimensional technology, applied in the direction of paper/cardboard containers, lamination, containers, etc., can solve the problems of their us

Inactive Publication Date: 2010-07-29
NANYANG TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since such isolated biological materials normally show different mechanical properties upon re-implantation, their use is limited since they do not resemble the same mechanical properties as the original tissue they are derived from.

Method used

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  • Three-dimensional porous hybrid scaffold and manufacture thereof
  • Three-dimensional porous hybrid scaffold and manufacture thereof
  • Three-dimensional porous hybrid scaffold and manufacture thereof

Examples

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[0153]In the following section the general setup of the examples for the manufacture of a hybrid scaffold of the present invention is described in more detail before referring to some specific examples carried out.

[0154]The purpose of producing a hybrid scaffold is to combine the advantages of both biocompatible polymers with that of acellular matrices for tissue engineering application.

[0155]FIGS. 2a and b show a schematic diagram of the electrospinning process. In this process, long and fine threads are drawn from droplets of polymer by the application of a high voltage electric field. The resulting nano-fibers are deposited onto a rotating mandrel (collector) to form a tubular interconnected porous network. The collector can be in any geometrical shapes other than the cylindrical mandrel used in this particular embodiment. Many different materials have been electrospun alone or in combinations using different solvents. Some examples are given in the following reviews (Huang, Z.-M...

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Abstract

The present invention refers to a three-dimensional porous hybrid scaffold for tissue engineering and methods of its manufacture and use.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of priority of U.S. provisional application No. 60 / 872,800, filed Dec. 5, 2006, the contents of it being hereby incorporated by reference in its entirety for all purposes.FIELD OF THE INVENTION[0002]The present invention refers to a three-dimensional porous hybrid scaffold for tissue engineering and methods of its manufacture and use.BACKGROUND OF THE INVENTION[0003]Biological materials have been used in many tissue engineering applications to control the function and structure of engineered tissue by interacting with transplanted / host cells. These materials include naturally derived materials (e.g. collagen and alginate) and acellular tissue matrices (e.g. small intestinal submucosa) among others. Biological materials have been proven to support cell ingrowth and regeneration of damaged tissues with no evidence of immunogenic rejection, and encourage the remodeling process by stimulating cells to synth...

Claims

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Application Information

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IPC IPC(8): C12N5/00B32B37/12B32B37/16
CPCA61L27/3847A61L27/56Y10T156/10A61L27/60D01D5/0076A61L27/58A61L27/38C08J9/00
Inventor CHIAN, KERM SINLEONG, MENG FATTGOPAL, PAMELA E-WEIRATNER, BUDDY DENNIS
Owner NANYANG TECH UNIV
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