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Pouch-Like Construct for Preventing Heart Distension

a construct and a technology of a pouch are applied in the field of pouch-like constructs to prevent heart distension, which can solve the problems of drug use, arrhythmias or leakage of cardiac valves, and at best delay the natural progression of most cardiac diseases

Inactive Publication Date: 2010-07-01
TISSUE SYST HLDG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With each type of cardiac dilation, serious problems are associated which may include arrhythmias or leakage of the cardiac valves.
Yet, drugs can at best delay the natural progression of most cardiac diseases.
Complete healing of myocardial dilation or heart failure has not been achieved so far.
Despite positive trials in Europe and North America, the use of cardiac support devices (CSD) has recently been stopped by the U.S. Food and Drug Administration due to safety concerns.
It has been found that pericardial constriction may occur in patients with cardiac support devices making reoperations necessary which are technically challenging (Schroder et al.
However, the generation of engineered tissue is technically challenging, since the size of the constructs appears to be limited by the maximum diffusion distances for nutrients and oxygen.
Therefore, it was not possible so far to construct larger three-dimensional tissue constructs which are suitable to be used for stabilizing a large mammalian heart suffering from cardiac dilation.

Method used

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  • Pouch-Like Construct for Preventing Heart Distension
  • Pouch-Like Construct for Preventing Heart Distension
  • Pouch-Like Construct for Preventing Heart Distension

Examples

Experimental program
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examples

Statistical Analysis

[0053]Data are presented as mean±standard error of the mean. Statistical differences were determined using a repeated ANOVA (contraction experiments). A P value of <0.05 was considered statistically significant.

Methods and Materials

[0054]All procedures were approved by the local animal protection authority (BWG of the Freie and Hansestadt Hamburg: #54 / 04) and conformed to the Guide for the Care and Use of Laboratory Animals (NIH publication 86-23, revised 1996).

Cell Isolation

[0055]Cardiac myocytes were isolated from neonatal Wistar rats (postnatal on day 0-3) by a fractionated DNase / Trypsin digestion protocol as described in Zimmermann W H, et al. (2000), Biotechnol Bioeng, 68:106-14. The resulting cell population which consisted of approximately 50% cardiomoycytes and 50% non-myocytes (Naito H, et al. (2006). Circulation 114:I 72-8) was immediately subjected to EHT generation

Construction of a Casting Mold for a Pouch-Like Construct

[0056]A novel casting mold was ...

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Abstract

The invention is directed to a pouch-like construct comprising mammalian tissue which can be used for preventing distension and / or resisting dilation of the heart in a mammal. Preferably, the pouch-like tissue construct has contractile properties. The invention further relates to a method for the preparation of a pouch-like construct comprising mammalian tissue which can be used for the above purposes.

Description

FIELD OF THE INVENTION[0001]The invention is directed to a pouch-like construct comprising mammalian tissue which can be used for preventing distension and / or resisting dilation of the heart in a mammal. Preferably, the pouch-like tissue construct has contractile properties. The invention further relates to a method for the preparation of a pouch-like construct comprising mammalian tissue which can be used for the above purposes.BACKGROUND OF THE INVENTION[0002]Cardiac dilation is a common clinical phenomenon observed in several cardiac diseases, such as post-myocardial infarction and heart failure. In an early stage of cardiac dilation, the organ enlargement may be restricted to only a portion of the heart, such as the left ventricle. In an advanced stage, the complete heart may be enlarged. With each type of cardiac dilation, serious problems are associated which may include arrhythmias or leakage of the cardiac valves. Cardiac dilation is a frequent reason for subjecting a patien...

Claims

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Application Information

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IPC IPC(8): C12N11/14C12N11/00C12N11/04
CPCA61F2/2481A61L27/38A61L27/54A61L2300/412A61K35/34A61F2240/001A61L2300/414
Inventor ZIMMERMANN, WOLFRAM-HUBERTUSESCHENHAGEN, THOMASYILDIRIM, YALIN
Owner TISSUE SYST HLDG
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