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Particles for inhalation having sustained release properties

a technology of inhalation and particle, which is applied in the direction of phosphorous compound active ingredients, aerosol delivery, drug compositions, etc., can solve the problem of rapid release of agents, and achieve the effects of reducing the initial release of agents that are typically seen in inhalation therapy, increasing the amount of time, and increasing patient compliance and comfor

Inactive Publication Date: 2008-10-16
MASSACHUSETTS INST OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach provides a sustained release profile, prolonging the presence of therapeutic levels of bioactive agents in the systemic and local circulation, reducing the frequency of dosing and improving patient compliance by minimizing initial peak levels, as demonstrated with insulin and other agents like albuterol and estrone sulfate.

Problems solved by technology

However, delivery of bioactive agents to the pulmonary system typically results in rapid release of the agent following administration.

Method used

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  • Particles for inhalation having sustained release properties
  • Particles for inhalation having sustained release properties
  • Particles for inhalation having sustained release properties

Examples

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Embodiment Construction

[0028] A description of preferred embodiments of the invention follows.

[0029] Therapeutic, prophylactic or diagnostic agents, can also be referred to herein as “bioactive agents,”“medicaments” or “drugs.”

[0030] The invention relates to a method for the pulmonary delivery of therapeutic, prophylactic and diagnostic agents comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent. The agent is released from the administered particles in a sustained fashion.

[0031] The particles of the invention release bioactive agent in a sustained fashion. As such, the particles possess sustained release properties. “Sustained release”, as that term is used herein, refers to a release of active agent in w...

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Abstract

The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

Description

RELATED APPLICATIONS [0001] This application is a continuation of U.S. application Ser. No. 09 / 752,106, filed Dec. 29, 2000, which is a continuation-in-part of application Ser. No. 09 / 394,233, filed Sep. 13, 1999, which is a continuation-in-part of application Ser. No. 08 / 971,791, filed Nov. 17, 1997, now U.S. Pat. No. 5,985,309, which claims the benefit of U.S. Provisional Application No. 60 / 059,004, filed Sep. 15, 1997. [0002] This application is also related to application Ser. No. 09 / 337,245, filed Jun. 22, 1999; Ser. No. 09 / 383,054, filed on Aug. 25, 1999; Ser. No. 09 / 382,959, filed Aug. 25, 1999; Ser. No. 09 / 644,320, filed on Aug. 23, 2000; Ser. No. 09 / 665,252, filed Sep. 19, 2000, now U.S. Pat. No. 6,514,482; 09 / 644,105, filed Aug. 23, 2000; Ser. No. 09 / 644,736, filed Aug. 23, 2000; and Ser. No. 09 / 591,307, filed Jun. 9, 2000. The entire teachings of the above applications are incorporated herein by reference. GOVERNMENT SUPPORT [0003] This invention was made with government ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/14A61L9/04A61K38/00A61K9/00A61K9/16A61K31/135A61K31/137A61K38/28A61K38/38A61K47/48
CPCA61K9/0075A61K9/1617A61K9/1623A61K9/1641A61K9/1647A61K9/1658A61K9/1694A61K31/135A61K31/137A61K38/28A61K38/38A61K47/48876A61K31/566A61K47/6927A61K9/0073A61K9/16A61K47/12A61K47/24
Inventor EDWARDS, DAVID A.LANGER, ROBERT S.VANBEVER, RITAMINTZES, JEFFREYWANG, JUECHEN, DONGHAO
Owner MASSACHUSETTS INST OF TECH
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