Method for fostering bone formation and preservation

Abstract

A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] The present application is a divisional of U.S. patent application Ser. No. 11 / 128,095, filed May 11, 2005, which is a 35 U.S.C. §119 conversion of U.S. Provisional Application No. 60 / 571,200, filed May 14, 2004, the contents of which are specifically incorporated herein.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] The invention disclosed herein was made with Government support under NIH Grant No. DE 12110 from the National Institutes of Health. Accordingly, the government has certain rights in this invention.FIELD OF THE INVENTION [0003] The present invention relates generally to a method for fostering bone formation in a subject. More particularly the invention concerns a method for inducing rapid bone formation and then preserving the bone thus produced, e.g., by minimizing its resorption. The invention permits specific targeting of particular bones of a subject for repair, strengthening, reshaping and / or mo...

AI Technical Summary

Benefits of technology

"The present invention provides a method for inducing rapid bone formation in a subject by mechanically inducing an increase in osteoblast activity and elevating blood concentration of at least one bone anabolic agent therein. The method can be used to treat bone fractures, reduce the duration of bone anabolic agent treatment, and prevent and treat bone marrow crush. It can also be used to induce bone formation in specific bones and to reduce resorption of new bone. The invention provides a kit for carrying out the method."

Problems solved by technology

Such prior art methods for treating these disorders are typically systemic in nature, however.

These methods are therefore not commonly able to be targeted on one or more specific bones, e.g., those of the hip, shoulder, spine and / or wrist, which may require a more focused treatment due to bone losses due to disease effects caused by, e.g., osteoporosis or by bone trauma such as that due to a fracture.

Moreover, prior art methods frequently require undesirably long treatment regimens, with accompanying patient compliance problems.

Images