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Particles for inhalation having sustained release properties

a technology of inhalation and particle, which is applied in the direction of peptide/protein ingredients, inorganic non-active ingredients, metabolic disorders, etc., can solve the problem of rapid release of agents, and achieve the effect of reducing the initial release of agents that are typically seen in inhalation therapy, increasing the amount of time, and increasing patient compliance and comfor

Inactive Publication Date: 2008-02-14
CIVITAS THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach provides a sustained release profile, prolonging the presence of therapeutic levels of bioactive agents in the systemic and local circulation, reducing the frequency of dosing and enhancing patient compliance by minimizing initial peak levels, thereby offering a more effective and comfortable treatment option.

Problems solved by technology

However, delivery of bioactive agents to the pulmonary system typically results in rapid release of the agent following administration.

Method used

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  • Particles for inhalation having sustained release properties
  • Particles for inhalation having sustained release properties
  • Particles for inhalation having sustained release properties

Examples

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Embodiment Construction

[0027]A description of preferred embodiments of the invention follows.

[0028]Therapeutic, prophylactic or diagnostic agents, can also be referred to herein as “bioactive agents,”“medicaments” or “drugs.”

[0029]The invention relates to a method for the pulmonary delivery of therapeutic, prophylactic and diagnostic agents comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent. The agent is released from the administered particles in a sustained fashion.

[0030]The particles of the invention release bioactive agent in a sustained fashion. As such, the particles possess sustained release properties. “Sustained release,” as that term is used herein, refers to a release of active agent in which t...

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Abstract

The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

Description

RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 10 / 202,616, filed on Jul. 23, 2002, now U.S. Pat. No. 7,048,908, which is a continuation of U.S. application Ser. No. 09 / 752,109, filed Dec. 29, 2000, now abandoned, which relates to application Ser. No. 09 / 337,245, filed on Jun. 22, 1999, Ser. No. 09 / 383,054, filed on Aug. 25, 1999, now U.S. Pat. No. 6,956,021, Ser. No. 09 / 382,959, filed on Aug. 25, 1999, now U.S. Pat. No. 6,586,008, Ser. No. 09 / 644,320, filed on Aug. 23, 2000, Ser. No. 09 / 665,252 filed on Sep. 19, 2000, now U.S. Pat. No. 6,514,482, Ser. No. 09 / 644,105, filed on Aug. 23, 2000, now U.S. Pat. No. 6,749,835, Ser. No. 09 / 644,736 filed on Aug. 23, 2000, now abandoned and Ser. No. 09 / 591,307 filed on Jun. 9, 2000, now U.S. Pat. No. 6,858,199. This application also relates to application Ser. No. 09 / 394,233 filed on Sep. 13, 1999, now U.S. Pat. No. 6,652,737, which is a continuation of application Ser. No. 08 / 971,791 filed on Nov. 17...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/28A61P3/00A61K9/00A61K47/48A61K9/14A61K9/16A61K31/137A61K38/30A61K47/02A61K47/12A61K47/18A61L9/04A61P3/10A61P43/00
CPCA61K9/0075A61K9/1617Y10S514/958A61K47/48053A61K38/28A61K47/544A61P3/00A61P43/00A61P3/10
Inventor BASU, SUJIT K.HRKACH, JEFFREYLIPP, MICHAELELBERT, KATHARINAEDWARDS, DAVID A.
Owner CIVITAS THERAPEUTICS
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