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Antimicrobial hand wash

Inactive Publication Date: 2008-01-31
GOJO IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0005]This invention involves the creation of a soap through a saponification reaction and the creation of an amine salt for inclusion in the soap. Herein, “primary” relates to those acids and bases employed in the saponification reaction, while “secondary” relates to t

Problems solved by technology

Although these antimicrobial agents are used in numerous hand wash formulations, they are not without some detrimental properties.
Antimicrobial agents are typically irritating to the skin.
When soaps are used in conjunction with antimicrobial agents, they do not present the best of each of these desired properties.
Although the presence of the soap allows for a reduction in the amount of antimicrobial agent while maintaining a relatively high log kill, antimicrobial soap products tend to irritate the skin.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0045]While making soap through a saponification reaction of a primary nitrogenous base with a primary fatty acid, the addition of excess base was examined. Because the high pH resulting from excess base would be irritating and detrimental to the skin care properties of the hand wash, the excess base was neutralized with a second water soluble acid. For a first control (Control 1), a hand wash made without excess base was tested along side the hand wash containing excess base neutralized with the second acid. A second control (Control 2) excess base is present, but is not subsequently neutralized with the second acid. The hand washes included antimicrobial agent, namely triclosan. The base was monoethanolamine. The first acid was lauric acid, and the second was lactic acid.

[0046]The triclosan was dissolved in dipropylene glycol, to make an “active premix.” The monoethanolamine was added to the water and then the lauric acid was added. After allowing the saponification process to com...

example 2

[0047]Because there is a boost in the efficacy of the product due to the use of excess primary nitrogenous base and a secondary neutralizing acid, alternate bases were tested. The focus was to find suitable weaker bases that might be used, because weaker bases should further reduce the degree of skin irritation experienced when using a resultant antimicrobial hand wash. Samples were made using the same procedure as in Example 1, but with alternate bases. Because the bases had different molecular masses, the percentage used in each sample was different. This was done in order to ensure that the same number of moles were present in each sample, thus allowing for the same concentration of amine salt in the final hand wash. As mentioned the same formulation was used as in Example 1, but with the base, monoethanolamine, replaced with the following:

Alternate BasesTriethanolamine9.355 gEquistar, USAAminomethylpropanol5.525 gANGUS Chemical, USA(AMP-95)Tetrahydroxypropyl10.29 gBASF, USAethyl...

example 3

[0048]In this example, alternate acids were considered for use in neutralizing excess base present after the saponification reaction, i.e, to replace the lactic acid specifically used in Example 1. The samples were made in accordance with Example 1, except that the lactic acid was replaced with alternate acids. A sample was also created having excess base and no second acid addition. The samples were adjusted to pH: 9.2±0.10 with each acid, and then tested for log reduction properties. The acids tested were as follows:

AcidAmountpHLog ReductionNoneN / A10.151.6Hydrochloric acid47.66 g 9.193.1Phosphoric acid1.52 g9.173.5Sulfuric acid12.20 g 9.183.4Ascorbic acid4.68 g9.174.4Malic acid*1.87 g9.122.8Succinic acid1.75 g9.172.8Glycolic acid2.04 g9.163.0Acetic acid43.68 g 9.192.2

[0049]From the high pH sample, it is plain to see the amine salt is important for the efficacious properties of the hand wash. Of the different acids tested, all drastically improved the log reduction values for the h...

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Abstract

An antimicrobial hand wash includes a soap, an antimicrobial agent, and an amine salt. The amine salt is found to increase the antimicrobial efficacy of the hand wash. The amine salt produced through the reaction of monoethanolamine and lactic acid is of particular interest as a soap addition. In processes of this invention, it is possible to create the desired amine salt in the soap in situ.

Description

TECHNICAL FIELD[0001]The present invention generally relates to antimicrobial compositions, and, more articularly, relates to soaps that include an efficacy boosting chemical derived from the neutralization of a nitrogeneous base with a neutralizing acid.BACKGROUND OF THE INVENTION[0002]True soaps are created through a saponification reaction in which fats, more appropriately, fatty acids, are neutralized with a base. To ensure that the reaction is driven to completion, it is common practice to employ an excess of base. Because soaps are generally compatible with antimicrobial agents, they are often used in liquid antimicrobial hand washes. Such soap-based antimicrobial hand washes are found in numerous markets including healthcare, food services, and consumer.[0003]Antimicrobial agents are selected from a variety of classes, including bisguanidine (e.g., chlorhexidine digluconate), diphenyl compounds, benzyl alcohols, trihalocarbanilides, quaternary ammonium compounds, ethoxylated ...

Claims

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Application Information

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IPC IPC(8): A61K8/00
CPCA61K8/361A61K8/365A61K8/41A61Q17/005A61Q19/10C11D17/08C11D3/485C11D9/002C11D9/26C11D9/30C11D11/04C11D3/48A61P31/02
Inventor BARNHART, RONALD A.LERNER, DAVID P.
Owner GOJO IND INC
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