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Method for prevention and treatment of periodontal disease

a periodontal disease and periodontal disease technology, applied in the field of periodontal disease prevention and treatment, can solve the problems of poor oral health, more serious health problems, and poor breath of millions of people every year, and achieve the effects of convenient maintenance and improvement of oral health and/or hygiene, low cost and safe treatmen

Inactive Publication Date: 2007-12-20
ZICARE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013] In accordance with various embodiments and aspects of the present invention, methods for prevention and treatment of periodontal disease are provided. The exemplary methods provide a relatively inexpensive and safe treatment for facilitating maintenance and improvement of oral health and / or hygiene, such as through the prevention and / or treatment of gingivitis, periodontitis, bleeding and / or the like. In addition, exemplary oral health methods are relatively easy to use or perform, do not require a visit to a dentist office, and do not damage the surface of enamel or dental devices.
[0018] In accordance further embodiments, the viscous composition is designed to maintain the active ingredient(s) in contact with a surface for an extended period of time. Suitable active ingredients include cetylpyridinium chloride (CPC), zinc salts, other antimicrobial agents, and other ingredients to prevent and / or treat gum disease.

Problems solved by technology

Unfortunately, poor oral health affects millions of people every year.
Poor oral health may result in symptoms ranging from bad breath, tooth decay, and tooth discoloration, to more serious health problems, such as gingivitis, periodontitis, and even general health problems, such as heart disease, stroke, poorly controlled diabetes and preterm labor.
The presence of dental plaque, or simply plaque, in an oral cavity can lead to such oral and general health problems.
If not removed, however, the presence of plaque can give rise to tartar formation, gum bleeding, tooth decay, gingivitis, periodontitis, and other health problems.
Tartar adheres to hard surfaces such as enamel, roots, and dental devices, such as orthodontia (e.g., braces), dentures, bridges, crowns, fillings, and the like, and is generally more difficult to remove than plaque.
Brushing and flossing are normally not sufficient to remove tartar from a surface.
If left untreated, tartar buildup can be problematic in several regards.
The bacteria growth can, in turn, lead to gum bleeding, tooth decay, gingivitis, periodontitis, and other health problems.
Although such toothpastes, if used regularly, may prevent buildup of additional tartar, the toothpastes are not thought to be effective at removing existing tartar from tooth enamel and dental device surfaces.
Although these techniques work well, they are relatively expensive and time consuming.
Furthermore, various methods for inhibiting tartar may cause damage to tooth enamel and / or to dental devices.

Method used

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  • Method for prevention and treatment of periodontal disease
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  • Method for prevention and treatment of periodontal disease

Examples

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specific examples

[0080] The following non-limiting examples illustrate improvement in oral health using a system, kit, and method in accordance with various embodiments of the invention. These examples are merely illustrative, and it is not intended that the invention be limited to the examples. Kits, systems, and compositions in accordance with the present invention may include the ingredients listed below as well as additional and / or alternative inert materials, preservatives, and other constituents typically found in compositions for promoting oral health. In the case where exemplary inert materials and / or preservatives are listed, these ingredients are merely exemplary, and it is understood that other similar ingredients may be substituted for the materials listed in the examples below.

example 1

[0081] A pale light pink viscous gel, having a viscosity of about 40,000 cp, with cinnamon-clove characteristic odor and taste is formed by admixing the following ingredients, as described above, in the amounts shown. The composition was sealed in system 500, illustrated in FIG. 5.

TABLE 1ExemplaryIngredientSupplierWeight %Wt % RangePurified WaterCopacker91.504    80-99Glycerin USPAcme-Hardesty5.000  0.01-15HEC 250 HXHercules-Aqualon2.000  0.01-10SorbitolRoquette0.050  0.001-0.5SucraloseTate & Lyle0.400  0.001-1.5CetylpyridiniumDishman0.100  0.001-1ChloridePharmaceuticalsZinc GluconateAmerican0.592  0.001-1.5USPInternationalCinnamon BarkSpectrum0.250  0.001-2(Oil)Clove Bud (Oil)Spectrum0.005  0.001-2Red #40 (1% sol.)Pylam0.0990.000005-1

[0082] A clinical study, including 24 subjects, evaluating the efficacy of the composition of Table 1 was conducted. Subjects were scored at baseline, three weeks, and at six weeks using the Low and Silness Gingival Index (1963) (GI) and the Turesky ...

example 2

[0086] A pale light pink viscous gel, having a viscosity of about 40,000 cp, with cinnamon-clove characteristic odor and taste is formed by admixing the following ingredients, as described above, in the amounts shown. The composition was sealed in system 500, illustrated in FIG. 5.

TABLE 2ExemplaryIngredientSupplierWeight %Wt % RangePurified WaterCopacker92.096    80-99Glycerin USPAcme-Hardesty5.000  0.01-15HEC 250 HXHercules-Aqualon2.000  0.01-10SorbitolRoquette0.050  0.001-0.5SucraloseTate & Lyle0.400  0.001-1.5CetylpyridiniumDishman0.100  0.001-1ChloridePharmaceuticalsCinnamon BarkSpectrum0.250  0.001-2(Oil)Clove Bud (Oil)Spectrum0.005  0.001-2Red #40 (1% sol.)Pylam0.0990.000005-1

[0087] A clinical study, including 22 subjects, evaluating the efficacy of the composition of Example 2 was conducted. The Low and Silness Gingival Index (1963) (GI) for subjects using the formula of Table 2 for a six-week period showed a greater performance than a placebo in both absolute (0.405) and p...

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Abstract

A composition for prevention and / or treatment of periodontal disease, a system including the composition, a method of using the composition and system, and a method of forming the composition and system are disclosed. The composition designed to maintain contact with a portion of an oral cavity for an extended period of time to, for example, prevent and / or reduce an amount of gingivitis, periodontitis, bleeding and / or the like. The system includes a composition and a container encapsulating the composition. The composition can be applied by rupturing the container and applying the composition through the ruptured portion of the container.

Description

CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Provisional Patent Application Ser. No. 60 / 800,632, entitled SYSTEM FOR MEASURABLY IMPROVING ORAL HEALTH AND METHOD OF USING SAME, filed May 15, 2006.FIELD OF INVENTION [0002] The present invention generally relates to methods for prevention and treatment of periodontal disease. More particularly, the invention relates to methods for using a composition, system, and kit for treating and / or prevention onset of periodontal disease. BACKGROUND OF THE INVENTION [0003] Unfortunately, poor oral health affects millions of people every year. Poor oral health may result in symptoms ranging from bad breath, tooth decay, and tooth discoloration, to more serious health problems, such as gingivitis, periodontitis, and even general health problems, such as heart disease, stroke, poorly controlled diabetes and preterm labor. [0004] The presence of dental plaque, or simply plaque, in an oral cavity can lead t...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/18A61K8/21A61K8/22A61K8/24A61Q11/00
CPCA61K8/27A61K8/365A61Q11/00A61K8/731A61K8/4926
Inventor CLAROT, TIMMISKEWITZ, REGINA
Owner ZICARE
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