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Hydrophilized bactericidal polymers

Inactive Publication Date: 2007-03-01
PURDUE RES FOUND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0004] The present invention is directed to polymeric compositions providing improved bactericidal, hydrophilicity / wettability, and biocompatibility characteristics. In particular, the present invention provides a bactericidal composition, including a hydrophilic first comonomer polymerized to a second comonomer to form a polymeric composition, where the polymeric composition is more soluble and / or more bactericidal in an aqueous solution than either of the first comonomer or the second comonomer alone.
[0006] In another example, the present invention provides a method for rendering a material or area bactericidal in which a bactericidal composition of the present invention is applied to a medium or device in an amount suitable for killing or significantly reducing the number of bacteria in or on the treated medium or device compared to an untreated medium or device.
[0007] In another example, the present invention provides a method for killing or significantly reducing the number of bacteria on a material or area treated with a bactericidal composition of the present invention.

Problems solved by technology

In some instances the bactericidal property is most apparent in an insoluble form, which is not particularly amenable to killing microorganisms.
Application of bactericidal polymers may also be limited by their use in brushes, their insolubility in solution, or by their unfavorable biocompatibility characteristics.

Method used

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Examples

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examples

[0059] 1. Radical Polymerization and Quaternization. Copolymers possessing suitable bactericidal properties and a suitable hydrophilicity / biocompatibility profile were obtained using a quaternized polymeric composition synthesized from 4-vinylpyridine and a biocompatible, hydrophilic comonomer, such as hydroxyethylmethacrylate (HEMA) or poly(ethyleneglycol) methacrylate.

[0060] Copolymers were synthesized by radical copolymerization with AIBN as initiator. The reactants were stirred at 70° C. for 48 hours under flowing N2 to prevent oxidation. As the monomer contents were varied, the AIBN proportion was held constant to a massic ratio VP+PEGMA:AIBN equal to 22:1. To investigate the effects of hydrophilization, seven different compositions of VP with PEGMA300, PEGMA 1100 and HEMA were synthesized, containing a molar percentage of VP of 10, 25, 50, 75, 90, 95 and 99.

[0061] Copolymers were quaternized with a 3-fold excess of hexyl bromide (HB) in a mixture of chloroform and methanol b...

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Abstract

A bactericidal polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal polymers, methods for rendering materials bactericidal, and methods for using bactericidal compositions to kill or reduce bacterial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; and / or wound dressings.

Description

[0001] This application claims the benefit of priority under 35 U.S.C. § 119(e) to U.S. Provisional Application No. 60 / 711,234, filed Aug. 24, 2005, which is hereby incorporated by reference in its entirety.BACKGROUND [0002] There is an ever-growing demand for materials suitable for killing harmful microorganisms. Such materials could be used to coat surfaces of common objects touched by people to render them antiseptic so as to prevent transmission of bacterial infections or to facilitate the killing of microorganisms in solution. [0003] Various polycations are known to have bactericidal properties. However, their bactericidal properties can be strongly influenced by whether the polycation or a composition containing the polycation is soluble. In some instances the bactericidal property is most apparent in an insoluble form, which is not particularly amenable to killing microorganisms. In other instances the bactericidal activity is lost when the polycation is cross-linked or other...

Claims

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Application Information

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IPC IPC(8): A61K31/787C12Q1/18
CPCC12Q1/18C08F220/286C08F220/281C08F226/08A01N43/40C08F226/06
Inventor YOUNGBLOOD, JEFFREY P.SELLENET, PHILIPPE
Owner PURDUE RES FOUND INC
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